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Cell cycle events associated with the termination of proliferation by cytotoxic and differentiation-inducing actions of 6-thioguanine on HL-60 cells.
Delayed growth arrest was observed in HL-60 acute promyelocytic leukemia cells after exposure to 6-thioguanine (TG). This growth arrest occurred in both wild-type HL-60 cells exposed to 2 microM TG… Expand
Alterations in glycoprotein synthesis and guanosine triphosphate levels associated with the differentiation of HL-60 leukemia cells produced by inhibitors of inosine 5'-phosphate dehydrogenase.
The exposure of HL-60 leukemia cells to inhibitors of IMP dehydrogenase caused a marked reduction in the incorporation of [3H]mannose into both cellular glycoproteins and their lipid-linked oligosaccharide precursors; these effects are presumably due to the pronounced decrease in intracellular levels of guanosine triphosphate produced by blockage of IMP dehydration. Expand
Cell-cycle position and nuclear protein content.
Dual parameter FCM analysis based on nuclear DNA and protein content provides a more complete definition of cell cycle position than DNA content alone. Expand
Analysis of glycosaminoglycans of flow sorted cells: incorporation of [35S]sulfate and [3H]glucosamine into glycosaminoglycans of B16-F10 cells during the cell cycle.
Comparison of the degree of sulfation of short-term with long-term labeled cells suggests that highly sulfated glycosaminoglycans may be turned over more rapidly during G1 and G2 + M phases of the cell cycle. Expand
The effect of hyperthermia on the protein content of HeLa cell nuclei: a flow cytometric analysis.
Electronic volume determinations in conjunction with microscopically measured volume indicate that the electrical resistance is reduced in nuclei from heate... Expand
Differentiation of HL-60 promyelocytic leukemia cells: simultaneous determination of phagocytic activity and cell cycle distribution by flow cytometry.
Analysis of two-parameter correlated data indicated that phagocytosis is coupled with residence in the G1/G0 phase of the cell cycle, further suggesting that the ability to phagocytetize fluorescent microspheres is associated with end-stage differentiation. Expand
UV irradiation of lymphocytes triggers an increase in intracellular Ca2+ and prevents lectin-stimulated Ca2+ mobilization: evidence for UV- and nifedipine-sensitive Ca2+ channels.
- H. Spielberg, C. June, O. Blair, C. Nystrom-Rosander, N. Cereb, H. Deeg
- Chemistry, Medicine
- Experimental hematology
- 1 September 1991
The data indicate that UV and gamma irradiation have different effects on lymphocyte membranes and suggest that a disruption of Ca2+ homeostasis may be involved in UV-induced lymphocyte inhibition. Expand
Differentiation of HL-60 promyelocytic leukemia cells monitored by flow cytometric measurement of nitro blue tetrazolium (NBT) reduction.
In the present study, the differentiation of HL-60 leukemia cells induced by dimethylsulfoxide (DMSO) or retinoic acid was monitored by flow cytometric measurement of forward and 90 degree light scatter of NBT treated cells. Expand
Differentiation of WEHI-3B D+ monomyelocytic leukemia cells by retinoic acid and aclacinomycin A.
The studies support the idea that this cell line would be a particularly good model for extrapolation of findings with differentiating agents in culture to therapeutic monitoring in animals, since WEHI-3B D+ leukemia cells can be readily propagated in vivo in BALB/c mice. Expand
Fibroblast growth factor-4 enhanced G2 arrest and cell survival following ionizing radiation.
- M. Jung, F. Kern, T. Jorgensen, S. McLeskey, O. Blair, A. Dritschilo
- Biology, Medicine
- Cancer research
- 1 October 1994
It is reported here that FGF-4 enhances cellular capacity to survive ionizing radiation and cell cycle analysis shows a pronounced increase in the duration of G2 arrest, suggesting perturbation of a cell cycle checkpoint, implicate fibroblast growth factor-mediated signal transduction in cellular resistance of human tumors to radiation therapy. Expand