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Zidovudine

Known as: 3'-Azido-2',3'-Dideoxythymidine, Azidothymidine, Antiviral AZT 
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the… 
National Institutes of Health

Related topics

Related topics

37 relations

Narrower (18)

3'-azido-3'-deoxyarabinothymidine3'-azido-3'-deoxythymidine monophosphate diglyceride4'-azidothymidine4'-azidothymidine 5'-triphosphate
Acquired Immunodeficiency SyndromeHIVHIV InfectionsIn Blood

Broader (2)

Anti-HIV AgentsThymidine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Triple-Antiretroviral Prophylaxis to Prevent Mother-To-Child HIV Transmission through Breastfeeding—The Kisumu Breastfeeding Study, Kenya: A Clinical Trial
Timothy Thomas and colleagues report the results of the Kisumu breastfeeding study (Kenya), a single-arm trial that assessed the… 
Review
2009
Review
2009
Coinfection with Hepatitis C Virus and Human Immunodeficiency Virus: Virological, Immunological, and Clinical Outcomes
Infection with hepatitis C virus (HCV) is estimated to affect 2% of the world population ([90][1]) and is a leading cause of… 
Highly Cited
2007
Highly Cited
2007
Mutations in the connection domain of HIV-1 reverse transcriptase increase 3′-azido-3′-deoxythymidine resistance
We previously proposed that a balance between nucleotide excision and template RNA degradation plays an important role in… 
Highly Cited
2005
Highly Cited
2005
KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis.
Highly Cited
2002
Highly Cited
2002
The Molecular Mechanism of Multidrug Resistance by the Q151M Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Its Suppression Using α-Boranophosphate Nucleotide Analogues*
Nucleoside analogues are currently used to treat human immunodeficiency virus infections. The appearance of up to five… 
Highly Cited
2001
Highly Cited
2001
Anti-AIDS agents. 42. Synthesis and anti-HIV activity of disubstituted (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone analogues.
A series of disubstituted 3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogues (1-10) were synthesized and evaluated for… 
Highly Cited
1999
Highly Cited
1999
The susceptibility to X4 and R5 human immunodeficiency virus-1 strains of dendritic cells derived in vitro from CD34(+) hematopoietic progenitor cells is primarily determined by their maturation…
Dendritic cells (DC) were sorted on day 8 from cultures of CD34(+) cells with stem cell factor/Flt-3 ligand/ granulocyte… 
Highly Cited
1993
Highly Cited
1993
CD4+ Lymphocytes Are an Incomplete Surrogate Marker for Clinical Progression in Persons with Asymptomatic HIV Infection Taking Zidovudine
Identifying a valid surrogate end point for serious clinical events associated with human immunodeficiency virus (HIV) infection… 
Highly Cited
1992
Highly Cited
1992
Longitudinal study of parotid saliva in HIV-1 infection.
Parotid flow rate and chemistry of 78 HIV + gay/bisexual men and 27 HIV-gay/bisexual controls were compared on a longitudinal… 
Highly Cited
1988
Highly Cited
1988
3′‐Azido‐3′‐deoxythymidine (AZT) inhibits proliferation in vitro of human haematopoietic progenitor cells
Peripheral blood cytopenias are a serious, dose‐limiting toxicity of AZT therapy in patients infected by HIV. To evaluate the… 
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