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Zidovudine

Known as: 3'-Azido-2',3'-Dideoxythymidine, Azidothymidine, Antiviral AZT 
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the… 
National Institutes of Health

Related topics

Related topics

37 relations

Narrower (18)

3'-azido-3'-deoxyarabinothymidine3'-azido-3'-deoxythymidine monophosphate diglyceride4'-azidothymidine4'-azidothymidine 5'-triphosphate
Acquired Immunodeficiency SyndromeHIVHIV InfectionsIn Blood

Broader (2)

Anti-HIV AgentsThymidine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging.
In the domain of health, one important challenge is the efficient delivery of drugs in the body using non-toxic nanocarriers… 
Highly Cited
2000
Highly Cited
2000
Marginal structural models to estimate the causal effect of zidovudine on the survival of HIV-positive men.
Standard methods for survival analysis, such as the time-dependent Cox model, may produce biased effect estimates when there… 
Review
2000
Review
2000
A family of drug transporters: the multidrug resistance-associated proteins.
The human multidrug resistance-associated protein (MRP) family currently has seven members. The ability of several of these… 
Highly Cited
1997
Highly Cited
1997
Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy.
BACKGROUND The new protease inhibitors are potent inhibitors of the human immunodeficiency virus (HIV), and in combination with… 
Highly Cited
1996
Highly Cited
1996
Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine. AIDS Clinical Trials Group.
BACKGROUND In patients with human immunodeficiency virus (HIV) infection, combined treatment with several agents may increase the… 
Highly Cited
1994
Highly Cited
1994
Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.
BACKGROUND AND METHODS Maternal-infant transmission is the primary means by which young children become infected with human… 
Review
1990
Review
1990
Mitochondrial myopathy caused by long-term zidovudine therapy.
Both infection with the human immunodeficiency virus type 1 (HIV) and zidovudine (formerly called azidothymidine [AZT]) cause… 
Highly Cited
1989
Highly Cited
1989
HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy.
The drug sensitivities of human immunodeficiency virus (HIV) isolates from a group of patients with acquired immunodeficiency… 
Highly Cited
1987
Highly Cited
1987
The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial.
We conducted a double-blind, placebo-controlled trial of the efficacy of oral azidothymidine (AZT) in 282 patients with the… 
Highly Cited
1985
Highly Cited
1985
3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.
The acquired immune deficiency syndrome (AIDS) is thought to result from infection of T cells by a pathogenic human retrovirus… 
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