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Zidovudine
Known as:
3'-Azido-2',3'-Dideoxythymidine
, Azidothymidine
, Antiviral AZT
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A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the…
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National Institutes of Health
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Related topics
Related topics
37 relations
Narrower (18)
3'-azido-3'-deoxyarabinothymidine
3'-azido-3'-deoxythymidine monophosphate diglyceride
4'-azidothymidine
4'-azidothymidine 5'-triphosphate
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Acquired Immunodeficiency Syndrome
HIV
HIV Infections
In Blood
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Broader (2)
Anti-HIV Agents
Thymidine
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Mutations in the connection domain of HIV-1 reverse transcriptase increase 3′-azido-3′-deoxythymidine resistance
G. Nikolenko
,
Krista A. Delviks-Frankenberry
,
+4 authors
V. Pathak
Proceedings of the National Academy of Sciences…
2007
Corpus ID: 33095312
We previously proposed that a balance between nucleotide excision and template RNA degradation plays an important role in…
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Highly Cited
2005
Highly Cited
2005
KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis.
Kevin S. Harris
,
W. Brabant
,
Sheila M Styrchak
,
A. Gall
,
R. Daifuku
Antiviral Research
2005
Corpus ID: 23929063
Highly Cited
2002
Highly Cited
2002
Azidothymidine causes functional and structural destruction of mitochondria, glutathione deficiency and HIV-1 promoter sensitization.
Tokio Yamaguchi
,
I. Katoh
,
S. Kurata
European Journal of Biochemistry
2002
Corpus ID: 18923877
Mitochondrial functional and structural impairment and generation of oxidative stress have been implicated in aging, various…
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Highly Cited
2000
Highly Cited
2000
Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3'-azido-3'-deoxythymidine.
Mariana Gerschenson
,
Stephen W . Erhart
,
+7 authors
Miriam C. Poirier
AIDS Research and Human Retroviruses
2000
Corpus ID: 22597280
3'-azido-3'-deoxythymidine (AZT) is given to pregnant women positive for the human immunodeficiency virus type 1 (HIV-1) to…
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Highly Cited
1999
Highly Cited
1999
The susceptibility to X4 and R5 human immunodeficiency virus-1 strains of dendritic cells derived in vitro from CD34(+) hematopoietic progenitor cells is primarily determined by their maturation…
B. Canque
,
Youssef Bakri
,
Sandrine Camus
,
M. Yagello
,
Abdelaziz Benjouad
,
J. Gluckman
Blood
1999
Corpus ID: 22497559
Dendritic cells (DC) were sorted on day 8 from cultures of CD34(+) cells with stem cell factor/Flt-3 ligand/ granulocyte…
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Highly Cited
1998
Highly Cited
1998
Cellular Uptake Mechanism of Amino Acid Ester Prodrugs in Caco-2/hPEPT1 Cells Overexpressing a Human Peptide Transporter
Hyo-Kyung Han
,
D. Oh
,
G. Amidon
Pharmaceutical Research
1998
Corpus ID: 5825270
AbstractPurpose. This study characterized the cellular uptake mechanism and hydrolysis of the amino acid ester prodrugs of…
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Highly Cited
1993
Highly Cited
1993
CD4+ Lymphocytes Are an Incomplete Surrogate Marker for Clinical Progression in Persons with Asymptomatic HIV Infection Taking Zidovudine
Sungsub Choi
,
S. Lagakos
,
R. Schooley
,
P. Volberding
Annals of Internal Medicine
1993
Corpus ID: 11447744
Identifying a valid surrogate end point for serious clinical events associated with human immunodeficiency virus (HIV) infection…
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Highly Cited
1989
Highly Cited
1989
Specific interaction of aurintricarboxylic acid with the human immunodeficiency virus/CD4 cell receptor.
D. Schols
,
M. Baba
,
R. Pauwels
,
J. Desmyter
,
E. D. Clercq
Proceedings of the National Academy of Sciences…
1989
Corpus ID: 21418588
The triphenylmethane derivative aurintricarboxylic acid (ATA), but not aurin, selectively prevented the binding of OKT4A/Leu-3a…
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Highly Cited
1988
Highly Cited
1988
3′‐Azido‐3′‐deoxythymidine (AZT) inhibits proliferation in vitro of human haematopoietic progenitor cells
N. Dainiak
,
M. Worthington
,
M. Riordan
,
Sandra Kreczko
,
Lyle S. Goldman
British Journal of Haematology
1988
Corpus ID: 22933977
Peripheral blood cytopenias are a serious, dose‐limiting toxicity of AZT therapy in patients infected by HIV. To evaluate the…
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Highly Cited
1988
Highly Cited
1988
Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity
J. Sommadossi
,
R. Carlisle
,
R. Schinazi
,
Zhu Zhou
Antimicrobial Agents and Chemotherapy
1988
Corpus ID: 13363877
We evaluated the effects of natural purine and pyrimidine nucleosides on protection from or reversal of 3'-azido-3…
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