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Zidovudine

Known as: 3'-Azido-2',3'-Dideoxythymidine, Azidothymidine, Antiviral AZT 
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the… 
National Institutes of Health

Related topics

Related topics

37 relations

Narrower (18)

3'-azido-3'-deoxyarabinothymidine3'-azido-3'-deoxythymidine monophosphate diglyceride4'-azidothymidine4'-azidothymidine 5'-triphosphate
Acquired Immunodeficiency SyndromeHIVHIV InfectionsIn Blood

Broader (2)

Anti-HIV AgentsThymidine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Mutations in the connection domain of HIV-1 reverse transcriptase increase 3′-azido-3′-deoxythymidine resistance
We previously proposed that a balance between nucleotide excision and template RNA degradation plays an important role in… 
Highly Cited
2005
Highly Cited
2005
KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis.
Highly Cited
2002
Highly Cited
2002
Azidothymidine causes functional and structural destruction of mitochondria, glutathione deficiency and HIV-1 promoter sensitization.
Mitochondrial functional and structural impairment and generation of oxidative stress have been implicated in aging, various… 
Highly Cited
2000
Highly Cited
2000
Fetal mitochondrial heart and skeletal muscle damage in Erythrocebus patas monkeys exposed in utero to 3'-azido-3'-deoxythymidine.
3'-azido-3'-deoxythymidine (AZT) is given to pregnant women positive for the human immunodeficiency virus type 1 (HIV-1) to… 
Highly Cited
1999
Highly Cited
1999
The susceptibility to X4 and R5 human immunodeficiency virus-1 strains of dendritic cells derived in vitro from CD34(+) hematopoietic progenitor cells is primarily determined by their maturation…
Dendritic cells (DC) were sorted on day 8 from cultures of CD34(+) cells with stem cell factor/Flt-3 ligand/ granulocyte… 
Highly Cited
1998
Highly Cited
1998
Cellular Uptake Mechanism of Amino Acid Ester Prodrugs in Caco-2/hPEPT1 Cells Overexpressing a Human Peptide Transporter
AbstractPurpose. This study characterized the cellular uptake mechanism and hydrolysis of the amino acid ester prodrugs of… 
Highly Cited
1993
Highly Cited
1993
CD4+ Lymphocytes Are an Incomplete Surrogate Marker for Clinical Progression in Persons with Asymptomatic HIV Infection Taking Zidovudine
Identifying a valid surrogate end point for serious clinical events associated with human immunodeficiency virus (HIV) infection… 
Highly Cited
1989
Highly Cited
1989
Specific interaction of aurintricarboxylic acid with the human immunodeficiency virus/CD4 cell receptor.
The triphenylmethane derivative aurintricarboxylic acid (ATA), but not aurin, selectively prevented the binding of OKT4A/Leu-3a… 
Highly Cited
1988
Highly Cited
1988
3′‐Azido‐3′‐deoxythymidine (AZT) inhibits proliferation in vitro of human haematopoietic progenitor cells
Peripheral blood cytopenias are a serious, dose‐limiting toxicity of AZT therapy in patients infected by HIV. To evaluate the… 
Highly Cited
1988
Highly Cited
1988
Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity
We evaluated the effects of natural purine and pyrimidine nucleosides on protection from or reversal of 3'-azido-3… 
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