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Zidovudine
Known as:
3'-Azido-2',3'-Dideoxythymidine
, Azidothymidine
, Antiviral AZT
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A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the…
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National Institutes of Health
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Related topics
Related topics
37 relations
Narrower (18)
3'-azido-3'-deoxyarabinothymidine
3'-azido-3'-deoxythymidine monophosphate diglyceride
4'-azidothymidine
4'-azidothymidine 5'-triphosphate
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Acquired Immunodeficiency Syndrome
HIV
HIV Infections
In Blood
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Broader (2)
Anti-HIV Agents
Thymidine
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging.
P. Horcajada
,
T. Chalati
,
+16 authors
R. Gref
Nature materials
2010
Corpus ID: 205403820
In the domain of health, one important challenge is the efficient delivery of drugs in the body using non-toxic nanocarriers…
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Highly Cited
2000
Highly Cited
2000
Marginal structural models to estimate the causal effect of zidovudine on the survival of HIV-positive men.
M. Hernán
,
B. Brumback
,
J. Robins
Epidemiology
2000
Corpus ID: 25118752
Standard methods for survival analysis, such as the time-dependent Cox model, may produce biased effect estimates when there…
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Review
2000
Review
2000
A family of drug transporters: the multidrug resistance-associated proteins.
P. Borst
,
R. Evers
,
M. Kool
,
J. Wijnholds
Journal of the National Cancer Institute
2000
Corpus ID: 15836587
The human multidrug resistance-associated protein (MRP) family currently has seven members. The ability of several of these…
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Highly Cited
1997
Highly Cited
1997
Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy.
R. Gulick
,
J. Mellors
,
+9 authors
J. Chodakewitz
The New England journal of medicine
1997
Corpus ID: 30798035
BACKGROUND The new protease inhibitors are potent inhibitors of the human immunodeficiency virus (HIV), and in combination with…
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Highly Cited
1996
Highly Cited
1996
Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine. AIDS Clinical Trials Group.
A. Collier
,
R. Coombs
,
+12 authors
L. Corey
The New England journal of medicine
1996
Corpus ID: 35025316
BACKGROUND In patients with human immunodeficiency virus (HIV) infection, combined treatment with several agents may increase the…
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Highly Cited
1994
Highly Cited
1994
Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.
E. Connor
,
R. Sperling
,
+7 authors
R. Jacobson
The New England journal of medicine
1994
Corpus ID: 13457499
BACKGROUND AND METHODS Maternal-infant transmission is the primary means by which young children become infected with human…
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Review
1990
Review
1990
Mitochondrial myopathy caused by long-term zidovudine therapy.
M. Dalakas
,
I. Illa
,
G. Pezeshkpour
,
J. Laukaitis
,
B. Cohen
,
J. Griffin
The New England journal of medicine
1990
Corpus ID: 20362121
Both infection with the human immunodeficiency virus type 1 (HIV) and zidovudine (formerly called azidothymidine [AZT]) cause…
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Highly Cited
1989
Highly Cited
1989
HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy.
B. Larder
,
G. Darby
,
D. Richman
Science
1989
Corpus ID: 29911460
The drug sensitivities of human immunodeficiency virus (HIV) isolates from a group of patients with acquired immunodeficiency…
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Highly Cited
1987
Highly Cited
1987
The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial.
M. Fischl
,
D. Richman
,
+7 authors
R. Schooley
The New England journal of medicine
1987
Corpus ID: 19428690
We conducted a double-blind, placebo-controlled trial of the efficacy of oral azidothymidine (AZT) in 282 patients with the…
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Highly Cited
1985
Highly Cited
1985
3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.
H. Mitsuya
,
K. Weinhold
,
+6 authors
S. Broder
Proceedings of the National Academy of Sciences…
1985
Corpus ID: 10929504
The acquired immune deficiency syndrome (AIDS) is thought to result from infection of T cells by a pathogenic human retrovirus…
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