Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

ZAP70 protein, human

Known as: syk-related tyrosine kinase, human, Zeta-Chain Associated Protein Kinase, Zeta-Chain Associated Protein Kinase, 70kd 
Tyrosine-protein kinase ZAP-70 (619 aa, ~70 kDa) is encoded by the human ZAP70 gene. This protein plays a role in both tyrosine phosphorylation and… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
Tcell antigen receptor (TCR) ligation initiates tyrosine kinase activation, signaling complex assembly, and immune synapse… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Four types of phospholipase D (PLD), PLDα, β, γ, and δ, have been characterized in Arabidopsis, and they display different… Expand
  • figure 1
  • table I
  • figure 2
  • table II
  • figure 3
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Accumulating evidence indicates that the interdomain B regions of ZAP‐70 and Syk play pivotal roles in the coupling of T‐cell… Expand
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Cbl is an adaptor protein that functions as a negative regulator of many signalling pathways that start from receptors at the… Expand
Is this relevant?
Highly Cited
1998
Highly Cited
1998
SH2 domain proteins transmit intracellular signals initiated by activated tyrosine kinase-linked receptors. Recent three… Expand
Is this relevant?
Highly Cited
1998
Highly Cited
1998
ABSTRACT The c-Cbl protein is tyrosine phosphorylated and forms complexes with a wide range of signalling partners in response to… Expand
Is this relevant?
Highly Cited
1997
Highly Cited
1997
The Cbl protooncogene product has emerged as a novel negative regulator of receptor and non-receptor tyrosine kinases through… Expand
Is this relevant?
Highly Cited
1996
Highly Cited
1996
The threshold at which antigen triggers lymphocyte activation is set by the enzymes that regulate tyrosine phosphorylation. Upon… Expand
Is this relevant?
Highly Cited
1995
Highly Cited
1995
ZAP-70 is a 70-kDa protein tyrosine kinase, expressed exclusively in T cells and NK cells, and plays a critical role in mediating… Expand
Is this relevant?
Highly Cited
1994
Highly Cited
1994
We have previously described a type of selective T cell deficiency (STD) characterized by persistent infections reminiscent of… Expand
Is this relevant?