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ZAP70 protein, human

Known as: syk-related tyrosine kinase, human, Zeta-Chain Associated Protein Kinase, Zeta-Chain Associated Protein Kinase, 70kd 
Tyrosine-protein kinase ZAP-70 (619 aa, ~70 kDa) is encoded by the human ZAP70 gene. This protein plays a role in both tyrosine phosphorylation and… 
National Institutes of Health

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Related topics

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Cell Differentiation processCell ProliferationEnzyme GeneNatural Killer Cells

Broader (1)

ZAP-70 Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
The structure, regulation, and function of ZAP‐70
Summary:  The tyrosine ZAP‐70 (ζ‐associated protein of 70 kDa) kinase plays a critical role in activating many downstream signal… 
Highly Cited
2002
Highly Cited
2002
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies
Tcell antigen receptor (TCR) ligation initiates tyrosine kinase activation, signaling complex assembly, and immune synapse… 
Highly Cited
1999
Highly Cited
1999
Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase
Cbl is an adaptor protein that functions as a negative regulator of many signalling pathways that start from receptors at the… 
Highly Cited
1998
Highly Cited
1998
Tandem SH2 Domains Confer High Specificity in Tyrosine Kinase Signaling*
SH2 domain proteins transmit intracellular signals initiated by activated tyrosine kinase-linked receptors. Recent three… 
Highly Cited
1998
Highly Cited
1998
Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice
ABSTRACT The c-Cbl protein is tyrosine phosphorylated and forms complexes with a wide range of signalling partners in response to… 
Highly Cited
1998
Highly Cited
1998
Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide.
The Syk family of kinases, consisting of ZAP-70 and Syk, play essential roles in a variety of immune and non-immune cells. This… 
Highly Cited
1997
Highly Cited
1997
The Cbl Phosphotyrosine-binding Domain Selects a D(N/D)XpY Motif and Binds to the Tyr292Negative Regulatory Phosphorylation Site of ZAP-70*
The Cbl protooncogene product has emerged as a novel negative regulator of receptor and non-receptor tyrosine kinases through… 
Highly Cited
1996
Highly Cited
1996
Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling
The threshold at which antigen triggers lymphocyte activation is set by the enzymes that regulate tyrosine phosphorylation. Upon… 
Highly Cited
1994
Highly Cited
1994
Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.
TCR stimulation results in the tyrosine phosphorylation of a number of cellular substrates. We have recently identified a 70-kDa… 
Highly Cited
1992
Highly Cited
1992
A human transmembrane protein-tyrosine-phosphatase, PTP zeta, is expressed in brain and has an N-terminal receptor domain homologous to carbonic anhydrases.
Protein-tyrosine-phosphatases (PTPases, EC 3.1.3.48) play a crucial role in the regulation of protein tyrosine phosphorylation… 
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