ZAP70 protein, human

Known as: syk-related tyrosine kinase, human, Zeta-Chain Associated Protein Kinase, Zeta-Chain Associated Protein Kinase, 70kd 
Tyrosine-protein kinase ZAP-70 (619 aa, ~70 kDa) is encoded by the human ZAP70 gene. This protein plays a role in both tyrosine phosphorylation and… (More)
National Institutes of Health

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2006
2006
It is well known that T cell differentiation and maturation in the thymus is tightly controlled at multiple checkpoints. However… (More)
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2006
2006
The clinical course of patients with chronic lymphocytic leukemia (CLL) is heterogeneous with some patients requiring early… (More)
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Highly Cited
2003
Highly Cited
2003
B-cell chronic lymphocytic leukemia (B-CLL) is a heterogenous disease with a highly variable clinical course. Recent studies have… (More)
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Highly Cited
2002
Highly Cited
2002
Four types of phospholipase D (PLD), PLD alpha, beta, gamma, and delta, have been characterized in Arabidopsis, and they display… (More)
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Highly Cited
1998
Highly Cited
1998
The Syk family of kinases, consisting of ZAP-70 and Syk, play essential roles in a variety of immune and non-immune cells. This… (More)
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Review
1997
Review
1997
B oth T cell tolerance and productive T cell responses require the interaction of the TCR with specific MHC–peptide ligands… (More)
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1996
1996
Accumulating data show that the tyrosine protein kinase Zap-70 plays an essential role in T cell receptor-mediated signal… (More)
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1995
1995
ZAP-70 is a protein tyrosine kinase thought to play a critical role in T-cell receptor (TCR) signal transduction. During T-cell… (More)
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1995
1995
Engagement of the T cell antigen receptor (TCR) results in activation of several tyrosine kinases leading to tyrosine… (More)
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Highly Cited
1992
Highly Cited
1992
Protein-tyrosine-phosphatases (PTPases, EC 3.1.3.48) play a crucial role in the regulation of protein tyrosine phosphorylation… (More)
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