Skip to search formSkip to main contentSkip to account menu

ZAP-70 Kinase

Known as: ZAP-70 Protein, ZAP70, Syk Related Tyrosine Kinase 
A protein tyrosine kinase that is required for T-CELL development and T-CELL ANTIGEN RECEPTOR function.
National Institutes of Health

Related topics

Related topics

12 relations
In BloodProcess of secretionZAP70 Ag:PrThr:Pt:Tiss:Ord:Immune stainZAP70 gene

Narrower (2)

ZAP70 deficiencyZAP70 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1999
Highly Cited
1999
Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase
Cbl is an adaptor protein that functions as a negative regulator of many signalling pathways that start from receptors at the… 
Highly Cited
1998
Highly Cited
1998
Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice
ABSTRACT The c-Cbl protein is tyrosine phosphorylated and forms complexes with a wide range of signalling partners in response to… 
Highly Cited
1997
Highly Cited
1997
Brief Definitive Report Major Histocompatibility Complex Class I Molecules Modulate Activation Threshold and Early Signaling of T Cell Antigen Receptor–�/ � Stimulated by Nonpeptidic Ligands
  • 1997
  • Corpus ID: 6510326
Highly Cited
1996
Highly Cited
1996
Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling
The threshold at which antigen triggers lymphocyte activation is set by the enzymes that regulate tyrosine phosphorylation. Upon… 
Highly Cited
1996
Highly Cited
1996
Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation.
Highly Cited
1995
Highly Cited
1995
ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity
Engagement of the T cell antigen receptor (TCR) results in activation of several tyrosine kinases leading to tyrosine… 
Review
1995
Review
1995
The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes.
The T- and B-cell receptor (TCR and BCR) signal transduction processes involve a coordinated interplay between two classes of non… 
Highly Cited
1994
Highly Cited
1994
p56lck interacts via its src homology 2 domain with the ZAP-70 kinase
p56lck, a member of the src family of protein tyrosine kinases, is an essential component in T cell receptor (TCR) signal… 
Highly Cited
1993
Highly Cited
1993
T cell activation by clustered tyrosine kinases
1986
1986
Either exogenous or endogenous fibronectin can promote adherence of human endothelial cells.
Recently, we have presented evidence that proliferating blood vessels produce and deposit fibronectin in situ during the… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)