ZAP-70 Kinase

Known as: ZAP-70 Protein, ZAP70, Syk Related Tyrosine Kinase 
A protein tyrosine kinase that is required for T-CELL development and T-CELL ANTIGEN RECEPTOR function.
National Institutes of Health

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2013
2013
Macrophages act as the primary effector cells during Leishmania infection through production of reactive oxygen species (ROS) and… (More)
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Highly Cited
2008
Highly Cited
2008
We transduced chronic lymphocytic leukemia (CLL) cells lacking ZAP-70 with vectors encoding ZAP-70 or various mutant forms of ZAP… (More)
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2008
2008
ZAP-70 is a cytoplasmic protein tyrosine kinase that is required for T cell antigen receptor (TCR) signaling. Both mice and… (More)
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Highly Cited
2005
Highly Cited
2005
T cell receptor (TCR) activation and signaling precede immunological synapse formation and are sustained for hours after… (More)
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2003
2003
The TCR-mediated signals required to activate resting T cells have been well characterized; however, it is not known how TCR… (More)
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Highly Cited
1998
Highly Cited
1998
The c-Cbl protein is tyrosine phosphorylated and forms complexes with a wide range of signalling partners in response to various… (More)
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Highly Cited
1998
Highly Cited
1998
T-cell receptors (TCRs) upon binding to peptide-MHC ligands transduce signals in T lymphocytes. Tyrosine phosphorylations in the… (More)
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1995
1995
Engagement of the T cell antigen receptor (TCR) results in activation of several tyrosine kinases leading to tyrosine… (More)
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1994
1994
p56lck, a member of the src family of protein tyrosine kinases, is an essential component in T cell receptor (TCR) signal… (More)
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Highly Cited
1993
Highly Cited
1993
Many cellular recognition events in the immune system are initiated by aggregation of cell surface receptors that lack intrinsic… (More)
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