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Wnt Inhibitory Factor 1

Known as: WIF-1, WIF1 
Wnt inhibitory factor 1 (379 aa, ~42 kDa) is encoded by the human WIF1 gene. This protein plays a role in the negative regulation of Wnt signaling.
National Institutes of Health

Related topics

Related topics

13 relations
Beta-Catenin Accumulation PathwayEGF-Like DomainExtracellular SpacePitx2 Transcription Regulation Pathway
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Papers overview

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Review
2017
Review
2017
Epigenetics in cancer stem cells
Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of cells commonly termed “cancer stem cells… Expand
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Highly Cited
2014
Highly Cited
2014
Curcumin-loaded nanoparticles potently induce adult neurogenesis and reverse cognitive deficits in Alzheimer's disease model via canonical Wnt/β-catenin pathway.
Neurogenesis, a process of generation of new neurons, is reported to be reduced in several neurodegenerative disorders including… Expand
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Highly Cited
2014
Highly Cited
2014
MicroRNA-181a promotes tumor growth and liver metastasis in colorectal cancer by targeting the tumor suppressor WIF-1
BackgroundGiven the emerging role of microRNA in tumor disease progression, we investigated the association between microRNA… Expand
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Highly Cited
2013
Highly Cited
2013
HOTAIR, a prognostic factor in esophageal squamous cell carcinoma, inhibits WIF-1 expression and activates Wnt pathway.
Long non-coding RNAs (LncRNAs) have been recently found to be pervasively transcribed in the genome and critical regulators of… Expand
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2010
2010
Transcriptional profiles predict disease outcome in patients with cutaneous T-cell lymphoma.
PURPOSE Average survival of cutaneous T-cell lymphoma (CTCL) is associated with clinical stage at diagnosis, where stage I has a… Expand
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Highly Cited
2009
Highly Cited
2009
Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice.
Wnt signaling increases bone mass by stimulating osteoblast lineage commitment and expansion and forms the basis for novel… Expand
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Highly Cited
2009
Highly Cited
2009
Aberrant methylation of APC, MGMT, RASSF2A, and Wif-1 genes in plasma as a biomarker for early detection of colorectal cancer.
PURPOSE To identify epigenetic molecular makers in plasma for the early detection of colorectal cancer. EXPERIMENTAL DESIGN We… Expand
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2008
2008
CpG island hypermethylation of E-cadherin (CDH1) and integrin alpha4 is associated with recurrence of early stage esophageal squamous cell carcinoma.
The prognosis of esophageal squamous cell carcinoma (ESCC) patients remains very poor, which is partially due to a high rate of… Expand
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2008
2008
A novel activity of the Dickkopf-1 amino terminal domain promotes axial and heart development independently of canonical Wnt inhibition.
The secreted Dickkopf-1 (Dkk1) protein mediates numerous cell fate decisions and morphogenetic processes. Its carboxyl terminal… Expand
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Highly Cited
2006
Highly Cited
2006
Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection.
PURPOSE Aberrant promoter hypermethylation of Wnt-antagonist genes contributes to the pathogenesis of several cancers. We… Expand
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