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Wnt Inhibitory Factor 1

Known as: WIF-1, WIF1 
Wnt inhibitory factor 1 (379 aa, ~42 kDa) is encoded by the human WIF1 gene. This protein plays a role in the negative regulation of Wnt signaling.
National Institutes of Health

Related topics

Related topics

13 relations
Beta-Catenin Accumulation PathwayEGF-Like DomainExtracellular SpacePitx2 Transcription Regulation Pathway

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
[Methylation Status and mRNA Expression of DKK-3 and WIF-1 in Acute Myeloid Leukemia Patients].
OBJECTIVE To analyze the promoter methylation status, mRNA expression and clinical significance of DKK-3 and WIF-1 genes in… 
2017
2017
WNT inhibitory factor 1 promoter hypermethylation is an early event during gallbladder cancer tumorigenesis that predicts poor survival.
2017
2017
Value of the level of methylation of RASSF1A and WIF-1 in tissue and serum in neoadjuvant chemotherapeutic assessment for advanced breast cancer
This study assessed the clinical efficacy of the neoadjuvant chemotherapy TAC scheme in treatment of patients with locally… 
2016
2016
Rescued expression of WIF-1 in gallbladder cancer inhibits tumor growth and induces tumor cell apoptosis with altered expression of proteins
As a highly conserved metabolic pathway, the Wnt signaling pathway is involved in cell differentiation, proliferation and several… 
2015
2015
pVAX-WIF-1真核表达载体的构建及其抗肺癌作用
  • N. AnXinmei Luo Wen Zhu
  • Zhongguo fei ai za zhi = Chinese journal of lung…
  • 2015
  • Corpus ID: 7107058
背景与目的 WIF-1是肺癌中重要的抑癌基因之一，其编码蛋白WIF-1能够通过抑制Wnt/β-catenin信号通路达到抑制肿瘤生长增殖及促进凋亡等抗肺癌作用。本研究旨在利用美国食品和药品管理委员会认可用于临床治疗的pVAX载体，构建pVAX-WIF-1… 
2013
2013
Rheumatoid arthritis: Uncoupling bone and cartilage destruction
trabecular bone than TNFtg mice did. More osteoclasts were found in TNFtg than in control mice; this increase was not observed in… 
2013
2013
Commensal Microbiota Contributes to Chronic Endocarditis in TAX1BP1 Deficient Mice
Tax1-binding protein 1 (Tax1bp1) negatively regulates NF-κB by editing the ubiquitylation of target molecules by its catalytic… 
2011
2011
Abstract 5475: Wnt pathway pharmacogenetics in lung cancer patients treated with platinum regimens
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Background: The Wnt/β-catenin signaling is important in… 
Review
2010
Review
2010
[Research progress of Wif1 in development of nervous system].
Wnt inhibitor factor-1 (WIF-1) is an extracellular antagonist of Wnts secreted proteins, first characterized as an expressed… 
2007
2007
[The role of secreted Wnt-antagonist genes hypermethylation in early detection of colorectal tumor].
OBJECTIVE To investigate the functions of promoter hypermethylation of secreted Wnt-antagonist genes in colorectal tumorigenesis… 
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