FAQ

Wnt Inhibitory Factor 1

Known as: WIF-1, WIF1 
Wnt inhibitory factor 1 (379 aa, ~42 kDa) is encoded by the human WIF1 gene. This protein plays a role in the negative regulation of Wnt signaling.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2004-2016
02420042016

Related topics

Related topics

10 relations
Extracellular SpaceSegmentation Clock PathwaySignal TransductionSignal Transduction Inhibition
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Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
Wnt Inhibitory Factor 1
Signal Transduction
Extracellular Space
Wnt Signaling Pathway
Wnt Signaling Pathway KEGG
WIF1 gene

Papers overview

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2017
2017
Wnt inhibitory factor 1 (WIF1) methylation and its association with clinical prognosis in patients with chondrosarcoma
Chondrosarcoma (CS) is a rare cancer, but it is the second most common primary malignant bone tumor and highly resistant to… (More)
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2015
2015
Wnts grasp the WIF domain of Wnt Inhibitory Factor 1 at two distinct binding sites.
Wnts have a structure resembling a hand with "thumb" and "index" fingers that grasp the cysteine rich domains of Frizzled… (More)
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2014
2014
Wnt inhibitory factor 1 suppresses cancer stemness and induces cellular senescence
Hyperactivation of the Wingless-type (Wnt)/β-catenin pathway promotes tumor initiation, tumor growth and metastasis in various… (More)
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2014
2014
Wnt inhibitory factor-1 functions as a tumor suppressor through modulating Wnt/β-catenin signaling in neuroblastoma.
Neuroblastoma is the most common extracranial solid tumor in childhood and is associated with serious morbidity and mortality… (More)
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2011
2011
The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence.
Gene expression-based prediction of genomic copy number aberrations in the chromosomal region 12q13 to 12q15 that is flanked by… (More)
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Highly Cited
2010
Highly Cited
2010
The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to…
Aberrations in the Wnt pathway have been reported to be involved in the metastasis of prostate cancer (PCa) to bone. We… (More)
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2010
2010
Prognostic value of Wnt inhibitory factor-1 expression in hepatocellular carcinoma that is independent of gene methylation
Recently, Wnt inhibitory factor-1 (WIF-1) was found to be epigenetically inactivated in several solid tumors, but the biological… (More)
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2009
2009
Wnt inhibitory factor (WIF)-1 inhibits osteoblastic differentiation in mouse embryonic mesenchymal cells.
Wnt inhibitory factor (WIF)-1 belongs to the members of secreted modulators of Wnt proteins. Secreted frizzled-related proteins… (More)
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Highly Cited
2004
Highly Cited
2004
Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer.
Aberrant activation of the Wingless-type (Wnt) signaling pathway is associated with a variety of human cancers, and we recently… (More)
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2004
2004
Hypermethylation in Human Lung Cancer Wnt Inhibitory Factor-1 Is Silenced by Promoter
Aberrant activation of the Wingless-type (Wnt) signaling pathway is associated with a variety of human cancers, and we recently… (More)
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