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WWP1 gene

Known as: WWP1, WW domain containing E3 ubiquitin protein ligase 1, DKFZP434D2111 
This gene plays a role in protein ubiquitination.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Chronic hypoxia causes pulmonary vascular remodeling leading to pulmonary hypertension (PH) and right ventricle (RV) hypertrophy… Expand
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Highly Cited
2009
Highly Cited
2009
HECT (homologous to the E6AP C terminus) ubiquitin ligases have diverse functions in eukaryotic cells. In screens for proteins… Expand
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Highly Cited
2008
Highly Cited
2008
Science has rapidly expanded its frontiers with new technologies in the 20th Century. Oceanography now is studied routinely by… Expand
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Highly Cited
2008
Highly Cited
2008
WWP1 E3 ubiquitin ligase has previously been shown to be frequently amplified and overexpressed in prostate and breast cancers… Expand
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Highly Cited
2007
Highly Cited
2007
The gene for E3 ubiquitin ligase WWP1 is located at 8q21, a region frequently amplified in human cancers, including prostate… Expand
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Highly Cited
2006
Highly Cited
2006
Genetic mutations that disrupt osteoblast function can result in skeletal dysmorphogenesis or, more rarely, in increased… Expand
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Highly Cited
2005
Highly Cited
2005
Many enveloped viruses exploit the class E vacuolar protein-sorting (VPS) pathway to bud from cells, and use peptide motifs to… Expand
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Highly Cited
2004
Highly Cited
2004
Smad7 negatively regulates transforming growth factor (TGF)-β superfamily signaling by binding to activated type I receptors… Expand
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Highly Cited
2004
Highly Cited
2004
Ubiquitin‐dependent degradation plays an important role in the negative regulation of TGF‐β signaling. Here, we identify Tiul1… Expand
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Highly Cited
2003
Highly Cited
2003
Ubiquitin ligases (E3) select proteins for ubiquitylation, a modification that directs altered subcellular trafficking and/or… Expand
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