• Publications
  • Influence
Complex splicing in the human T-cell leukemia virus (HTLV) family of retroviruses: novel mRNAs and proteins produced by HTLV type I
The results suggest that HTLV-I and other members of the HTLV family produce novel proteins, which may contribute to the biological properties of these viruses. Expand
Bovine leukemia virus transcription is controlled by a virus-encoded trans-acting factor and by cis-acting response elements
  • D. Derse
  • Medicine, Biology
  • Journal of virology
  • 1 August 1987
A series of cis-trans experiments using transfected virus gene constructs in different combinations revealed that expression of the 38-kDa protein was both necessary and sufficient to activate, in trans, the BLV promoter. Expand
Antiretroviral potential of human tripartite motif-5 and related proteins.
Overall, sporadic examples of intrinsic antiretroviral activity exist in this panel of TRIM proteins, and human TRIM5alpha modestly, but specifically, inhibited an HIV-1 strain carrying a mutation in the cyclophilin binding loop. Expand
Posttranscriptional effector domains in the Rev proteins of feline immunodeficiency virus and equine infectious anemia virus
The Rev proteins of feline immunodeficiency virus (FIV) and equine infectious anemia virus (EIAV) are studied to identify within each a short peptide that is functionally interchangeable with the effector domains found in Rev-like proteins from other retroviruses. Expand
Equine infectious anemia virus tat: insights into the structure, function, and evolution of lentivirus trans-activator proteins
The deduced amino acid sequence of EIAV tat, combined with functional analyses of tat cDNAs in transfected cells, has provided some unique insights into the domain structure of Tat. Expand
Quantitative Comparison of HTLV-1 and HIV-1 Cell-to-Cell Infection with New Replication Dependent Vectors
HTLV-1 Tax was demonstrated to play an important role in altering cell-cell interactions that enhance virus infection and replication, and superantigen-induced synapses between Jurkat cells and Raji/CD4 cells did not enhance infection for either HTLV- 1 or HIV-1. Expand
Interactions of Murine APOBEC3 and Human APOBEC3G with Murine Leukemia Viruses
It is found that mA3 inactivates MLV but is significantly less effective against MLV than is hA3G, and MLV has apparently evolved to partially resist the antiviral effects of mA 3 and to totally resist the ability ofmA3 to induce G-to-A mutation in viral DNA. Expand
HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication
It is reported that HTLV-1 has evolved a genetic function to restrict its own replication by a novel post-transcriptional mechanism, and p30II inhibits virus expression by reducing Tax and Rex protein expression. Expand
Identification of lentivirus tat functional domains through generation of equine infectious anemia virus/human immunodeficiency virus type 1 tat gene chimeras
Chimeric tat genes and chimeric viral promoters were constructed between the distantly related human immunodeficiency virus type 1 and equine infectious anemia virus and revealed that the EIAV Tat-responsive element recognition domain is formed by two distinct structural regions. Expand
Human T-Cell Leukemia Virus Type 1 Integration Target Sites in the Human Genome: Comparison with Those of Other Retroviruses
Comparing the integration sites of HTLV-1 with those of ASLV, HIV, simian immunodeficiency virus, MLV, and foamy virus, it is shown that global and local integration site preferences correlate with the sequence/structure of virus-encoded integrases, supporting the idea that integrase is the major determinant of retroviral integration site selection. Expand