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[11C]PIB in a nondemented population
TLDR
Elevated [11C]PIB binding in nondemented subjects suggests that [11 C]P IB amyloid imaging may be sensitive for detection of a preclinical Alzheimer disease state. Expand
Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ42 in humans
TLDR
Amyloid‐β42 (Aβ42) appears central to Alzheimer's disease pathogenesis and is a major component of amyloid plaques, and its decrease may reflect plaques acting as an Aβ42 “sink,” hindering transport of soluble A β42 between brain and CSF. Expand
Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration
TLDR
PET imaging data demonstrate that alterations in an organism's environment can produce profound biological changes that have important behavioral associations, including vulnerability to cocaine addiction. Expand
Cerebrospinal fluid tau and ptau181 increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease
TLDR
This work reports a positive linear relationship between CSF tau/ptau181 (primary constituents of neurofibrillary tangles) with the amount of cortical amyloid and observes a strong inverse relationship of cortical PIB binding with CSF Aβ42 but not for plasma Aβ species. Expand
Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site
TLDR
The use of a novel photoaffinity probe, WC-21, to identify the putative sigma-2 receptor binding site as PGRMC1 should stimulate the development of unique imaging agents and cancer therapeutics that target the sigma -2 receptor/PGRMC1 complex. Expand
PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys
TLDR
Evidence for a predisposition to self-administer cocaine based on D2 receptor availability is provided, and it is demonstrated that the brain dopamine system responds rapidly following cocaine exposure. Expand
Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories
TLDR
It is shown that, in mice, successful reconsolidation-updating paradigms for recent memories fail to attenuate remote memories, but by using an HDAC2-targeting inhibitor (HDACi) during reconsideration, even remote memories can be persistently attenuated. Expand
Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition
TLDR
Using PET, it is found that the spatial distribution of aerobic glycolysis in normal young adults correlates spatially with Aβ deposition in individuals with DAT and cognitively normal participants with elevated Aβ, suggesting a possible link between regional aerobic gly coolysis in young adulthood and later development of Alzheimer pathology. Expand
Potential antecedent marker of Alzheimer disease
TLDR
Elevated [C]PIB binding in nondemented subjects suggests that [C].PIB amyloid imaging may be sensitive for detection of a preclinical Alzheimer disease state, and longitudinal studies will be required to determine the association of elevated [C.]P IB binding and risk of developing dementia of the Alzheimer type. Expand
Evaluation of 5-ethynyl-2′-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system
TLDR
EdU staining is a fast, sensitive and reproducible method to study cell proliferation in the central nervous system and can be combined with BrdUStaining, providing a valuable tool of double labeling DNA synthesis, e.g., for tracking the two populations of neurons generated at different time points. Expand
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