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WT1 Proteins

Known as: Proteins, WT1, WT1 Gene Product, WT1 Protein 
Isoforms encoded by the WT1 Wilms tumor suppressor gene (GENES, WILMS TUMOR) and produced by alternative splicings. They are zinc finger-containing… 
National Institutes of Health

Related topics

Related topics

14 relations
Genes, Wilms TumorIn BloodNephroblastomaProcess of secretion

Broader (1)

Tumor Suppressor Proteins

Narrower (1)

WT1 protein, human

Papers overview

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2014
2014
Wt1 Is Involved in Leydig Cell Steroid Hormone Biosynthesis by Regulating Paracrine Factor Expression in Mice1
ABSTRACT Wilms tumor gene, Wt1, is abundantly expressed in testis Sertoli cells. Our recent study demonstrated that Wt1 is… 
2012
2012
Sex Reversal in C57BL/6J XY Mice Caused by Increased Expression of Ovarian Genes and Insufficient Activation of the Testis Determining Pathway
Sex reversal can occur in XY humans with only a single functional WT1 or SF1 allele or a duplication of the chromosome region… 
Highly Cited
2008
Highly Cited
2008
WT1 immunoreactivity in breast carcinoma: selective expression in pure and mixed mucinous subtypes
Current literature suggests that strong WT1 expression in a carcinoma of unknown origin virtually excludes a breast primary. Our… 
2008
2008
Potential of dendritic cell immunotherapy for relapse after allogeneic hematopoietic stem cell transplantation, shown by WT1 peptide‐ and keyhole limpet hemocyanin‐pulsed, donor‐derived dendritic…
Induction of leukemia‐specific immune responses is a promising treatment for acute myeloid leukemia. A 58‐year‐old woman received… 
2008
2008
CD134-allodepletion allows selective elimination of alloreactive human T cells without loss of virus-specific and leukemia-specific effectors.
Highly Cited
2006
Highly Cited
2006
A phase I/II trial of a WT1 (Wilms' tumor gene) peptide vaccine in patients with solid malignancy: safety assessment based on the phase I data.
OBJECTIVE We conducted a phase I study to investigate the safety of a weekly WT1 tumor vaccine therapy in patients with solid… 
Review
2006
Review
2006
Development of WT1 peptide cancer vaccine against hematopoietic malignancies and solid cancers.
Wild-type Wilms' tumor gene WT1 is highly expressed not only in hematopoietic malignancies, including leukemia and… 
Highly Cited
2004
Highly Cited
2004
Myeloma Cells Are Highly Sensitive to the Granule Exocytosis Pathway Mediated by WT1-Specific Cytotoxic T Lymphocytes
Purpose: Because WT1 is a universal tumor antigen, we examined the sensitivity of myeloma cells to WT1-specific cytotoxic T… 
Review
2002
Review
2002
Regulation of Gene Expression by WT1 in Development and Tumorigenesis
WT1 encodes a zinc finger transcription factor implicated in normal development and tumorigenesis. Germline mutation or deletion… 
Highly Cited
1994
Highly Cited
1994
Expression of WT1 protein in fetal kidneys and Wilms tumors.
BACKGROUND Wilms' tumors are embryonic kidney neoplasms believed to result from a perturbation in the development of the… 
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