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WP1066

Known as: (E)-3(6-bromopyridin-2-yl)-2-cyano-N-((S0-1-phenylethyl)acrylamide, JAK2 Inhibitor WP1066 
An orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. Upon oral administration, WP1066… 
National Institutes of Health

Related topics

Related topics

4 relations
NCIt Antineoplastic Agent TerminologyReceptor Tyrosine Kinase Inhibition

Broader (2)

PyridinesTyrphostins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Delayed Administration of WP1066, an STAT3 Inhibitor, Ameliorates Radiation-Induced Lung Injury in Mice
PurposeThe present study was designed to investigate the effects of WP1066, a specific inhibitor of STAT3 signaling, on radiation… 
2016
2016
Dexmedetomidine Acts via the JAK2/STAT3 Pathway to Attenuate Isoflurane-Induced Neurocognitive Deficits in Senile Mice
Background Previous studies showed that isoflurane-induced cognitive deficits could be alleviated by dexmedetomidine in young… 
Highly Cited
2014
Highly Cited
2014
STAT3 inhibitor WP1066 attenuates miRNA-21 to suppress human oral squamous cell carcinoma growth in vitro and in vivo.
Abnormalities in signal transducer and activator of transcription 3 (STAT3) are involved in the oncogenesis of oral squamous cell… 
2012
2012
The tumor microenvironment expression of p‐STAT3 influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models
Melanoma is a common and deadly tumor that upon metastasis to the central nervous system (CNS) has median survival duration of… 
2012
2012
Induction of Bv 8 expression by granulocyte-colony stimulating factor in CD 11 b + Gr 1 + cells : Key role of Stat 3 signaling
Background: Bv8 expression is strongly induced by G-CSF, but the mechanisms remain unknown. Results: Stat3 activation is required… 
2012
2012
Suicide Gene Reveals the Myocardial Neovascularization Role of Mesenchymal Stem Cells Overexpressing CXCR4 (MSCCXCR4)
Background Our previous studies indicated that MSCCXCR4 improved cardiac function after myocardial infarction (MI). This study… 
2011
2011
Low amino acids affect expression of 11β-HSD2 in BeWo cells through leptin-activated JAK-STAT and MAPK pathways
Maternal protein restriction diminishes placental 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) activity and causes fetal… 
2010
2010
Inhibition of JAK/STAT signaling pathway prevents high-glucose-induced increase in endothelin-1 synthesis in human endothelial cells
Emerging evidence demonstrates the involvement of endothelin-1 (ET-1) in the pathophysiology of cardiovascular disorders… 
Highly Cited
2009
Highly Cited
2009
A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells
The activation of signal transducer and activator of transcription 3 (STAT3) has been identified as a key mediator that drives… 
2007
2007
WP1066, a potent inhibitor of Jak2/STAT3 pathway inhibits pancreatic tumor growth both in vitro and in vivo
2393 Background: Pancreatic cancer is now the fourth leading cause of cancer-related mortality in United States. Its… 
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