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WP 631

Known as: WP-631, WP631 
National Institutes of Health

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2 relations

Broader (1)

Daunorubicin
analogs & derivatives

Papers overview

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Highly Cited
2007
Highly Cited
2007
Epithelial–mesenchymal interactions in keloid pathogenesis modulate vascular endothelial growth factor expression and secretion
Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis during the wound healing process. As epithelial… 
Highly Cited
2006
Highly Cited
2006
Mitotic Catastrophe Results in Cell Death by Caspase-Dependentand Caspase-Independent Mechanisms
Exposure of MDA-MB-231 and MCF-7/VP human breast carcinoma cells to theanthracyclines doxorubicin and WP631 induced polyploidy… 
Highly Cited
2005
Highly Cited
2005
TGF‐β‐induced expression of tissue inhibitor of metalloproteinases‐3 gene in chondrocytes is mediated by extracellular signal‐regulated kinase pathway and Sp1 transcription factor
Transforming growth factor (TGF‐β1) is a potent inducer of chondrogenesis and stimulant of cartilage extracellular matrix (ECM… 
Highly Cited
2005
Highly Cited
2005
A new bisintercalating anthracycline with picomolar DNA binding affinity.
A new bisintercalating anthracycline (WP762) has been designed, in which monomeric units of daunorubicin have been linked through… 
2002
2002
Induction of G(2)/M arrest and inhibition of c-myc and p53 transcription by WP631 in Jurkat T lymphocytes.
Highly Cited
2001
Highly Cited
2001
Identification of a Critical Sp1 Site within the Endoglin Promoter and Its Involvement in the Transforming Growth Factor-β Stimulation*
Endoglin, a component of the transforming growth factor-β (TGF-β) receptor complex expressed on endothelial cells, is involved in… 
Highly Cited
1999
Highly Cited
1999
Bisanthracycline WP631 inhibits basal and Sp1-activated transcription initiation in vitro.
An in vitro transcription assay was used to compare the capacity of the bisintercalating anthracycline WP631 (which displays a… 
Highly Cited
1998
Highly Cited
1998
Ultratight DNA binding of a new bisintercalating anthracycline antibiotic.
Differential scanning calorimetry and absorption spectroscopy were used to characterize the interaction of the new… 
Highly Cited
1997
Highly Cited
1997
Structure-based design of a new bisintercalating anthracycline antibiotic.
A new bisintercalating anthracycline antibiotic, WP631, has been designed and synthesized. The rational design of the new… 
Highly Cited
1997
Highly Cited
1997
Structure of a DNA-bisdaunomycin complex.
The application of detailed structural data bases has now culminated in the successful design of a new generation of… 
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