WP 631

Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis during the wound healing process. As epithelial… Expand

We have previously demonstrated that insulin-stimulated glucose metabolism, and not insulin per se, mediates the effects of… Expand

Exposure of MDA-MB-231 and MCF-7/VP human breast carcinoma cells to the anthracyclines doxorubicin and WP631 induced polyploidy… Expand

Transforming growth factor (TGF-beta1) is a potent inducer of chondrogenesis and stimulant of cartilage extracellular matrix (ECM… Expand

A new bisintercalating anthracycline (WP762) has been designed, in which monomeric units of daunorubicin have been linked through… Expand

WP631, a new DNA-binding drug that bisintercalates into DNA with high affinity, seems to be highly cytotoxic against Jurkat T… Expand

Endoglin, a component of the transforming growth factor-β (TGF-β) receptor complex expressed on endothelial cells, is involved in… Expand

An in vitro transcription assay was used to compare the capacity of the bisintercalating anthracycline WP631 (which displays a… Expand

Differential scanning calorimetry and absorption spectroscopy were used to characterize the interaction of the new… Expand

The application of detailed structural data bases has now culminated in the successful design of a new generation of… Expand