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WNK4 gene

Known as: WNK4, PROTEIN KINASE, LYSINE-DEFICIENT 4, PRKWNK4 
National Institutes of Health

Related topics

Related topics

1 relation
WNK1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Disease-causing R1185C mutation of WNK4 disrupts a regulatory mechanism involving calmodulin binding and SGK1 phosphorylation sites.
The R1185C mutation in WNK4 is associated with pseudohypoaldosteronism type II (PHAII). Unlike other PHAII-causing mutations in… 
2010
2010
WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway independent of SPAK/OSR1 pathway
WNK kinase is a subfamily of serine/threonine kinases. WNK1 and WNK4 were shown to stimulate NCC activity through SPAK and OSR1… 
2010
2010
Identification of a Novel WNK4 Mutation in Chinese Patients with Pseudohypoaldosteronism Type II
Background: It has been reported that mutations in WNK1 and WNK4 cause pseudohypoaldosteronism type II (PHA2), an autosomal… 
2010
2010
An emerging role for SPAK in NCC, NKCC, and blood pressure regulation.
The cloning of the related sodium chloride (NCC) and sodium potassium 2 chloride (NKCC) co-transporters in the early 1990s… 
2008
2008
Distinct pathways for the involvement of WNK4 in the signaling of hypertonicity and EGF
WNK4 kinase mutations produce the autosomal dominant disorder familial hyperkalemia and hypertension (FHH), also known as… 
2008
2008
The acidic motif of WNK4 is crucial for its interaction with the K channel ROMK.
2005
2005
Apical localization of renal K channel was not altered in mutant WNK4 transgenic mice.
2004
2004
Comparison of WNK4 and WNK1 kinase and inhibiting activities.
2004
2004
WNK4 Intron 10 Polymorphism Is Not Associated With Hypertension
Abstract—A polymorphism in intron 10 of the serine-threonine kinase with no lysine (K) 4 gene WNK4 (G→A, base 1156666 on… 
2003
2003
The Role of Wnk4 in Polygenic Hypertension: A Candidate Gene Analysis on Rat Chromosome 10
Abstract—Linkage analyses in experimental crosses of stroke-prone spontaneously hypertensive (SHRSP) and normotensive Wistar… 
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