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Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination.
TLDR
It is demonstrated that Spitz triggers the DER signaling cascade, a subset of developmental processes that are similar to those regulated by DER, the Drosophila EGF receptor homolog, and graded activation of this pathway may normally give rise to a repertoire of discrete cell fates in the ventral ectoderm.
Hypercalciuria in familial hyperkalemia and hypertension accompanies hyperkalemia and precedes hypertension: description of a large family with the Q565E WNK4 mutation.
TLDR
It is concluded that in FHH with WNK4 mutations, with time all affected subjects will apparently develop hypertension, and it is suggested that W NK4 interacts with a calcium channel or transporter.
Specific inhibition of the reverse transcriptase of human immunodeficiency virus type 1 and the chimeric enzymes of human immunodeficiency virus type 1 and type 2 by nonnucleoside inhibitors
TLDR
Analysis of the inhibition patterns of the chimeric RTs by calanolide A provided evidence that there is a segment between residues 94 and 157 in HIV-1 RT that is critical for inhibition, and the data suggest that there may be a second segment located between amino acids 225 and 427 that is also important for specifying susceptibility to the drug.
Increased urinary Na-Cl cotransporter protein in familial hyperkalaemia and hypertension.
TLDR
Urinary NCCT protein was about four times higher in FHH than in controls, which points to the pathogenetic mechanism for the clinical phenotype of FHH and the WNK4 mutation, supporting results in transgenic mice with the same mutation and in knockin mice with another mutation.
Catalytic properties of the reverse transcriptases of human immunodeficiency viruses type 1 and type 2.
TLDR
The two HIV RTs were shown to be substantially different one from the other in several of their properties and also distinct from other RTs thus far studied.
Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization.
TLDR
The results demonstrate that Mimp is a novel mitochondrial carrier homologue upregulated by Met-HGF/SF signal transduction, which leads to mitochondrial depolarization, and suggest novel links among tyrosine kinase signaling, mitochondrial function, and cellular bioenergetics.
Distinct pathways for the involvement of WNK4 in the signaling of hypertonicity and EGF
TLDR
The observation that WNK4‐induced MAP kinase stimulation caused by hypertonicity, but not that caused by EGF, is associated with W NK4 subcellular redistribution suggests that this redistribution has a role in WNK 4 signaling.
Mutational analysis of the ribonuclease H activity of human immunodeficiency virus 1 reverse transcriptase.
TLDR
A series of plasmids constructed that induce the expression of high levels of either wild-type or mutated forms of the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) suggest that, unlike the RT from murine leukemia virus (MuLV), it is difficult to genetically separate the catalytic domains responsible for the RNase H and DNA polymerase functions of HIV-1 RT.
Cognitive impairment is prevalent in pseudohypoparathyroidism type Ia, but not in pseudopseudohypoparathyroidism: possible cerebral imprinting of Gsα
Objective  Pseudohypoparathyroidism type Ia (PHP‐Ia) is a hereditary disorder characterized by resistance to multiple hormones that work via cAMP such as PTH and TSH, accompanied by typical skeletal
In vivo molecular imaging of met tyrosine kinase growth factor receptor activity in normal organs and breast tumors.
TLDR
It is demonstrated that Met activation in vivo by HGF/SF alters the hemodynamics of normal and malignant Met-expressing tissues and may be used for in vivo diagnosis, prognosis, and therapy of Met- expressing tumors.
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