FAQ

WNK1 gene

Known as: PPP1R167, KIAA0344, protein phosphatase 1, regulatory subunit 167 
This gene plays a role in regulation of electrolyte homeostasis.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2018
010203019952018

Related topics

Related topics

7 relations
Hereditary Sensory Autonomic Neuropathy, Type 2PhosphorylationSerine/Threonine PhosphorylationSignal Transduction
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WNK1 wt Allele

Related mentions per year

Related mentions per year

1938-2018
19401960198020002020
WNK1 gene
Signal Transduction
Phosphorylation
Serine/Threonine Phosphorylation
WNK4 gene
WNK1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1.
The SPAK (STE20/SPS1-related proline/alanine-rich kinase) and OSR1 (oxidative stress-responsive kinase-1) kinases interact and… (More)
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Highly Cited
2006
Highly Cited
2006
Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.
WNK kinases are serine-threonine kinases with an atypical placement of the catalytic lysine. Intronic deletions with increased… (More)
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Highly Cited
2005
Highly Cited
2005
The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases.
Mutations in the human genes encoding WNK1 [with no K (lysine) protein kinase-1] and the related protein kinase WNK4 are the… (More)
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Highly Cited
2005
Highly Cited
2005
WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.
The WNK1 and WNK4 genes have been found to be mutated in some patients with hyperkalemia and hypertension caused by… (More)
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Highly Cited
2005
Highly Cited
2005
WNK1 activates SGK1 to regulate the epithelial sodium channel.
WNK (with no lysine [K]) kinases are serine-threonine protein kinases with an atypical placement of the catalytic lysine… (More)
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Highly Cited
2005
Highly Cited
2005
Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport.
With-no-lysine (WNK) kinases are highly expressed along the mammalian distal nephron. Mutations in either WNK1 or WNK4 cause… (More)
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Highly Cited
2003
Highly Cited
2003
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
The availability of both the mouse and human genome sequences allows for the systematic discovery of human gene function through… (More)
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Highly Cited
2003
Highly Cited
2003
Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform.
WNK1 is a serine-threonine kinase, the expression of which is affected in pseudohypoaldosteronism type II, a Mendelian form of… (More)
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Highly Cited
2003
Highly Cited
2003
WNK1, a gene within a novel blood pressure control pathway, tissue-specifically generates radically different isoforms with and without a kinase domain.
WNK1 is a member of a novel serine/threonine kinase family, With-No-K, (lysine). Intronic deletions in the encoding gene cause… (More)
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Highly Cited
2000
Highly Cited
2000
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II.
We have cloned and characterized a novel mammalian serine/threonine protein kinase WNK1 (with no lysine (K)) from a rat brain… (More)
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