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WHSC1 protein, human

Known as: Wolf-Hirschhorn Syndrome Candidate 1 Protein, NSD2 protein, human, Protein Trithorax-5 
Histone-lysine N-methyltransferase NSD2 (1365 aa, ~152 kDa) is encoded by the human WHSC1 gene. This protein is involved in both histone methylation… 
National Institutes of Health

Related topics

Related topics

10 relations
Enzyme GeneMethylationMethyltransferase GenePHD Finger

Broader (2)

Histone-Lysine N-MethyltransferaseRepressor Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
Genetic mutations and features of mantle cell lymphoma: a systematic review and meta-analysis.
Mantle cell lymphoma (MCL) is an incurable rare subtype of non-Hodgkin lymphoma and is subject to relapse and therapeutic… 
Highly Cited
2017
Highly Cited
2017
AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis
Loss of phosphatase and tensin homolog (PTEN) and activation of the PI3K/AKT signaling pathway are hallmarks of prostate cancer… 
Highly Cited
2017
Highly Cited
2017
Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia.
Current standard of care for patients with pediatric acute lymphoblastic leukemia (ALL) is mainly effective, with high remission… 
Highly Cited
2016
Highly Cited
2016
MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents
MMSET/WHSC1 is a histone methyltransferase (HMT) overexpressed in t(4;14)+ multiple myeloma (MM) patients, believed to be the… 
Highly Cited
2012
Highly Cited
2012
Histone Methyltransferase NSD2/MMSET Mediates Constitutive NF-κB Signaling for Cancer Cell Proliferation, Survival, and Tumor Growth via a Feed-Forward Loop
ABSTRACT Constitutive NF-κB activation by proinflammatory cytokines plays a major role in cancer progression. However, the… 
Highly Cited
2012
Highly Cited
2012
Multiple myeloma-associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress.
The histone methyltransferase WHSC1 (also known as MMSET) is overexpressed in multiple myeloma (MM) as a result of the t(4;14… 
Review
2011
Review
2011
Cancers and the NSD family of histone lysine methyltransferases.
Highly Cited
2011
Highly Cited
2011
Wolf–Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage
Wolf–Hirschhorn syndrome (WHS) is a malformation syndrome associated with growth retardation, mental retardation, and… 
Highly Cited
2009
Highly Cited
2009
The Target of the NSD Family of Histone Lysine Methyltransferases Depends on the Nature of the Substrate
The NSD (nuclear receptor SET domain-containing) family of histone lysine methyltransferases is a critical participant in… 
2001
2001
A unique mRNA initiated within a middle intron of WHSC1/MMSET encodes a DNA binding protein that suppresses human IL-5 transcription.
Human interleukin (IL)-5 gene transcription is regulated by several transcription factor binding sites, including CLE 0, GATA… 
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