WFDC2 wt Allele

Known as: dJ461P17.6, EDDM4, HE4 
Human WFDC2 wild-type allele is located within 20q12-q13.2 and is approximately 12 kb in length. This allele, which encodes WAP four-disulfide core… (More)
National Institutes of Health

Related topics

Related topics

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20q12-q13.2Malignant neoplasm of ovaryProtein Degradation InhibitionRegulation of Proteolysis

Broader (1)

WFDC2 gene

Papers overview

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2012
2012
Serum levels of the ovarian cancer biomarker HE4 are decreased in pregnancy and increase with age.
OBJECTIVE The purpose of this study was to establish normal ranges for human epididymis protein 4 (HE4) serum levels in healthy… (More)
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Highly Cited
2010
Highly Cited
2010
Use of a Symptom Index, CA125, and HE4 to predict ovarian cancer.
BACKGROUND Prior studies suggest that combining the Symptom Index (SI) with a serum HE4 test or a CA125 test may improve… (More)
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Highly Cited
2009
Highly Cited
2009
HE4: a new potential early biomarker for the recurrence of ovarian cancer
Human epididymis protein 4 (HE4) has recently been described as a new marker for the early diagnosis of ovarian cancer (OC). The… (More)
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Highly Cited
2008
Highly Cited
2008
The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass.
OBJECTIVES The CA125 tumor marker is used to help predict the presence of ovarian cancer in patients with an adnexal mass… (More)
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Highly Cited
2008
Highly Cited
2008
Utility of a novel serum tumor biomarker HE4 in patients with endometrioid adenocarcinoma of the uterus.
OBJECTIVE Tumor markers with increased sensitivity and specificity for endometrial cancer are needed to help monitor response to… (More)
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Highly Cited
2006
Highly Cited
2006
WFDC2 (HE4): A potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung
BACKGROUND The Whey Acidic Protein domain is an evolutionarily conserved motif found in a number of proteins, the best studied of… (More)
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Highly Cited
2005
Highly Cited
2005
Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas.
Among the genes most commonly identified in gene expression profiles of epithelial ovarian carcinomas (EOC) is the gene for human… (More)
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Highly Cited
2005
Highly Cited
2005
Potential markers that complement expression of CA125 in epithelial ovarian cancer.
BACKGROUND When ovarian carcinoma is diagnosed in stage I, up to 90% of patients can be cured with surgery and currently… (More)
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Highly Cited
2003
Highly Cited
2003
The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma.
The WFDC2 (HE4) gene is amplified in ovarian carcinomas, whereas its expression in normal tissues, including ovary, is low… (More)
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Highly Cited
2002
Highly Cited
2002
The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms
The whey acidic protein (WAP) domain is a conserved motif, containing eight cysteines found in a characteristic 4-disulphide core… (More)
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