Viral Interleukin-6 Homolog

Known as: Putative Interleukin 6, ORF K2, vIL-6 
Viral interleukin-6 homolog (204 aa, ~23 kDa) is encoded by the human herpesvirus 8 K2 gene. This protein is involved in the negative regulation of… (More)
National Institutes of Health

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Genes, ViralHHV8 K2 GeneImmune ToleranceNegative Regulation of Apoptosis
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Papers overview

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Highly Cited
2010
Highly Cited
2010
An interleukin-6-related systemic inflammatory syndrome in patients co-infected with Kaposi sarcoma-associated herpesvirus and HIV but without Multicentric Castleman disease.
BACKGROUND Kaposi sarcoma-associated herpesvirus (KSHV) is the causal agent for Kaposi sarcoma (KS) and multicentric Castleman… (More)
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Highly Cited
1999
Highly Cited
1999
Involvement of interleukin-10 (IL-10) and viral IL-6 in the spontaneous growth of Kaposi's sarcoma herpesvirus-associated infected primary effusion lymphoma cells.
Primary effusion lymphoma (PEL) is a distinct type of lymphoma associated with Kaposi's sarcoma-associated herpesvirus (KSHV… (More)
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Highly Cited
1999
Highly Cited
1999
Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease.
Human herpesvirus 8 (HHV-8) infection has been implicated in the etiology of Kaposi's sarcoma (KS), primary effusion lymphoma… (More)
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Highly Cited
1999
Highly Cited
1999
Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6.
Kaposi's sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 [HHV-8]) is a herpesvirus linked to the… (More)
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Highly Cited
1999
Highly Cited
1999
KSHV-encoded viral IL-6 activates multiple human IL-6 signaling pathways.
Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) encodes a structural and functional homologue of human IL-6 called viral… (More)
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Highly Cited
1998
Highly Cited
1998
Human herpesvirus type 8 interleukin-6 homologue is functionally active on human myeloma cells.
Seroepidemiology and polymerase chain reaction studies have strongly suggested that human herpesvirus type 8 (HHV-8) is… (More)
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Highly Cited
1997
Highly Cited
1997
Human herpesvirus 8 encodes a homolog of interleukin-6.
Kaposi's sarcoma is a multifocal lesion that is reported to be greatly influenced by cytokines such as interleukin-6 (IL-6) and… (More)
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Highly Cited
1997
Highly Cited
1997
A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit.
The present studies analyzed the biologic activity of a gene product (vIL-6) encoded by the recently discovered Kaposi's sarcoma… (More)
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Highly Cited
1997
Highly Cited
1997
Expression of a virus-derived cytokine, KSHV vIL-6, in HIV-seronegative Castleman's disease.
Castleman's disease is a rare B cell lymphoproliferative disorder related to excess interleukin-6 (IL-6)-like activity. Kaposi's… (More)
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Highly Cited
1996
Highly Cited
1996
Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV.
Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon… (More)
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