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Viral Interleukin-6 Homolog

Known as: Putative Interleukin 6, ORF K2, vIL-6 
Viral interleukin-6 homolog (204 aa, ~23 kDa) is encoded by the human herpesvirus 8 K2 gene. This protein is involved in the negative regulation of… 
National Institutes of Health

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Related topics

7 relations
Genes, ViralHHV8 K2 GeneImmune ToleranceNegative Regulation of Apoptosis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Molecular biology of human herpesvirus 8: novel functions and virus-host interactions implicated in viral pathogenesis and replication.
Human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma-associated herpesvirus (KSHV), is the second identified human… 
2008
2008
A nuclear role for Kaposi's sarcoma-associated herpesvirus-encoded K13 protein in gene regulation
Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded viral FLICE inhibitory protein K13 interacts with a cytosolic IκB kinase… 
Review
2007
Review
2007
Investigational agents for treatment of AIDS-related Kaposi’s sarcoma
AIDS-related Kaposi’s sarcoma (KS) is a neoplasm that results from the co-infection of HIV and KS herpesvirus/human herpesvirus-8… 
Review
2006
Review
2006
Emerging targets and novel strategies in the treatment of AIDS‐related Kaposi's sarcoma: Bidirectional translational science
Through the mentorship process, Dr. Arthur Pardee emphasized the critical importance of bidirectional translational research—not… 
Review
2002
Review
2002
[Castleman's disease in patients infected with HIV].
PURPOSE Castleman's disease is a polyclonal lymphoplasmacytic and vascular proliferation prominant in lymphoid tissues. It is… 
2001
2001
[Quantitative analysis of human herpes virus type 8 and expression of its genes in patients with multiple myeloma].
OBJECTIVE To investigate if infection of human herpesvirus type 8 (HHV8) exists in Chinese patients with multiple myeloma (MM… 
1999
1999
Human herpesvirus 8-encoded interleukin 6 activates HIV-1 in the U1 monocytic cell line.
OBJECTIVE Human herpesvirus 8 (HHV-8) encodes a viral interleukin 6 (vIL-6) which is structurally and functionally similar to… 
1998
1998
Lack of serologic association between human herpesvirus-8 infection and multiple myeloma and monoclonal gammopathies of undetermined significance.
An interesting and provocative study by Rettig et al.(1) has raised the possibility that a virus—human herpesvirus 8 (HHV-8… 
1997
1997
A Kaposi ’ s Sarcoma-associated Herpesvirus-encoded Cytokine Homolog ( vIL-6 ) Activates Signaling through the Shared gp 130 Receptor Subunit
The present studies analyzed the biologic activity of a gene product (vIL-6) encoded by the recently discovered Kaposi’s sarcoma… 
1984
1984
Sequence of a cDNA encoding Basilea kappa light chains (K2 isotype) suggests a possible relationship of protein structure to limited expression
We present the complete sequence of a cDNA encoding rabbit immunoglobulin kappa light chains of the Basilea isotype (K2… 
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