Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.
- Y. Chang, E. Cesarman, P. Moore
- Biology, MedicineScience
- 16 December 1994
unique sequences present in more than 90 percent of Kaposi's sarcoma tissues obtained from patients with acquired immunodeficiency syndrome (AIDS) appear to define a new human herpesvirus.
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas.
- E. Cesarman, Y. Chang, P. Moore, J. Said, D. Knowles
- Medicine, BiologyNew England Journal of Medicine
- 4 May 1995
A high degree of conservation of KSHV sequences in Kaposi's sarcoma and in the eight lymphomas suggests the presence of the same agent in both lesions, suggesting that a novel herpesvirus has a pathogenic role in AIDS-related body-cavity-based lymphomas.
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8).
- J. Russo, R. Bohenzky, P. Moore
- BiologyProceedings of the National Academy of Sciences…
- 10 December 1996
Terminal repeat analysis of virus DNA from a KS lesion suggests a monoclonal expansion of KSHV in the KS tumor.
Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma
- H. Feng, M. Shuda, Yuan Chang, P. Moore
- BiologyScience
- 22 February 2008
In six of eight MCV-positive MCCs, viral DNA was integrated within the tumor genome in a clonal pattern, suggesting that MCV infection and integration preceded clonal expansion of the tumor cells, and MCV may be a contributing factor in the pathogenesis of MCC.
T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus
- M. Shuda, H. Feng, Yuan Chang
- BiologyProceedings of the National Academy of Sciences
- 21 October 2008
It is shown that tumor-derived virus mutations do not affect retinoblastoma tumor suppressor protein (Rb) binding by LT but do eliminate viral DNA replication capacity, suggesting that MCV-positive MCC tumor cells undergo selection for LT mutations to prevent autoactivation of integrated virus replication that would be detrimental to cell survival.
Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV
- P. Moore, C. Boshoff, R. Weiss, Yuan Chang
- Biology, MedicineScience
- 6 December 1996
Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon regulatory factor (IRF) are encoded by the Kaposi's sarcoma-associated…
KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma
- Shou-Jiang Gao, L. Kingsley, P. Moore
- Medicine, BiologyNature Network Boston
- 1 August 1996
Antibody kinetics showed that more than half of the AIDS–KS patients who were examined IgG–seroconverted before KS development, and antibody levels did not decline after seroconversion, suggest that the rate of infection was constant and that the risk of developing KS once infected with KSHV is not highly dependent on the duration of infection.
Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator.
- M. Shuda, H. Kwun, H. Feng, Yuan Chang, P. Moore
- Biology, ChemistryJournal of Clinical Investigation
- 1 September 2011
It is shown that MCV small T (sT) antigen is expressed in most MCC tumors, where it is required for tumor cell growth and its effects on dysregulated cap-dependent translation have clinical implications for the prevention, diagnosis, and treatment of MCV-related cancers.
The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear…
- L. Rainbow, G. Platt, T. Schulz
- BiologyJournal of Virology
- 1 August 1997
It is demonstrated that orf73 encodes the 222- to 234-kDa LNA, is a component of LANA, and is expressed in KS tumor cells, as well as the characteristic speckled nuclear immunofluorescence pattern ofLANA on Western blots.
In vitro establishment and characterization of two acquired immunodeficiency syndrome-related lymphoma cell lines (BC-1 and BC-2) containing Kaposi's sarcoma-associated herpesvirus-like (KSHV) DNA…
- E. Cesarman, P. Moore, P. Rao, G. Inghirami, D. Knowles, Y. Chang
- BiologyBlood
- 1 October 1995
It is demonstrated that the KSHV sequences represent a portion of a much larger DNA molecule that is located predominantly in the nucleus of the infected cells, and that their presence in the cells as large nuclear episomes supports previous sequence homology data suggesting that K SHV belongs to the herpesvirus family.
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