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Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma.
unique sequences present in more than 90 percent of Kaposi's sarcoma tissues obtained from patients with acquired immunodeficiency syndrome (AIDS) appear to define a new human herpesvirus. Expand
Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas.
A high degree of conservation of KSHV sequences in Kaposi's sarcoma and in the eight lymphomas suggests the presence of the same agent in both lesions, suggesting that a novel herpesvirus has a pathogenic role in AIDS-related body-cavity-based lymphomas. Expand
Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8).
Terminal repeat analysis of virus DNA from a KS lesion suggests a monoclonal expansion of KSHV in the KS tumor. Expand
Clonal Integration of a Polyomavirus in Human Merkel Cell Carcinoma
In six of eight MCV-positive MCCs, viral DNA was integrated within the tumor genome in a clonal pattern, suggesting that MCV infection and integration preceded clonal expansion of the tumor cells, and MCV may be a contributing factor in the pathogenesis of MCC. Expand
T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus
It is shown that tumor-derived virus mutations do not affect retinoblastoma tumor suppressor protein (Rb) binding by LT but do eliminate viral DNA replication capacity, suggesting that MCV-positive MCC tumor cells undergo selection for LT mutations to prevent autoactivation of integrated virus replication that would be detrimental to cell survival. Expand
Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV
Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon regulatory factor (IRF) are encoded by the Kaposi's sarcoma-associatedExpand
KSHV antibodies among Americans, Italians and Ugandans with and without Kaposi's sarcoma
Antibody kinetics showed that more than half of the AIDS–KS patients who were examined IgG–seroconverted before KS development, and antibody levels did not decline after seroconversion, suggest that the rate of infection was constant and that the risk of developing KS once infected with KSHV is not highly dependent on the duration of infection. Expand
The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear
It is demonstrated that orf73 encodes the 222- to 234-kDa LNA, is a component of LANA, and is expressed in KS tumor cells, as well as the characteristic speckled nuclear immunofluorescence pattern ofLANA on Western blots. Expand
Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator.
It is shown that MCV small T (sT) antigen is expressed in most MCC tumors, where it is required for tumor cell growth and its effects on dysregulated cap-dependent translation have clinical implications for the prevention, diagnosis, and treatment of MCV-related cancers. Expand
Transcription Mapping of the Kaposi’s Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Genome in a Body Cavity-Based Lymphoma Cell Line (BC-1)
Results indicate that BC-1 cells have detectable transcription of a number of KSHV genes, particularly nonconserved genes involved in cellular signal transduction and regulation, during noninduced (latent) virus culture. Expand