Skip to search formSkip to main contentSkip to account menu

VWF gene

Known as: Von Willebrand Factor Gene, VWF, FACTOR VIII-VON WILLEBRAND FACTOR 
This gene is critical for cellular homeostasis and plays a role in the regulation of blood coagulation by platelet function modulation. Mutations in… 
National Institutes of Health

Related topics

Related topics

11 relations
Blood coagulationHemophilia AHomeostasisLigand Binding

Narrower (1)

VWF wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1997
Highly Cited
1997
Proteolytic cleavage of recombinant type 2A von Willebrand factor mutants R834W and R834Q: inhibition by doxycycline and by monoclonal antibody VP-1.
The susceptibility of recombinant type 2A von Willebrand factor (vWF) to a recently identified plasma metalloproteinase and the… 
Highly Cited
1996
Highly Cited
1996
Mocarhagin, a novel cobra venom metalloproteinase, cleaves the platelet von Willebrand factor receptor glycoprotein Ibalpha. Identification of the sulfated tyrosine/anionic sequence Tyr-276-Glu-282…
Platelet adhesion to the subendothelium is the initiating event in hemostasis and thrombosis and involves the binding of von… 
Highly Cited
1996
Highly Cited
1996
Binding of a novel 50-kilodalton alboaggregin from Trimeresurus albolabris and related viper venom proteins to the platelet membrane glycoprotein Ib-IX-V complex. Effect on platelet aggregation and…
Binding of the multimeric adhesive glycoprotein, von Willebrand Factor (vWF), to the platelet membrane glycoprotein (GP) Ib-IX-V… 
Highly Cited
1995
Highly Cited
1995
Functional and sequence characterization of agkicetin, a new glycoprotein Ib antagonist isolated from Agkistrodon acutus venom. offf2p4.
A new glycoprotein Ib (GPIb) antagonist, agkicetin, was purified from the venom of Agkistrodon acutus and characterized. It is a… 
Highly Cited
1993
Highly Cited
1993
Protein kinase C is activated in platelets subjected to pathological shear stress.
Highly Cited
1990
Highly Cited
1990
Ristocetin and Botrocetin Involve Two Distinct Domains of von Willebrand Factor for Binding to Platelet Membrane Glycoprotein lb
Summary We have evidence that ristocetin and botrocetin mediate binding of von Willebrand Factor (vWF) to platelet glycoprotein… 
Highly Cited
1989
Highly Cited
1989
Role of botrocetin in platelet agglutination: formation of an activated complex of botrocetin and von Willebrand factor
Botrocetin (venom coagglutinin) induces binding of von Willebrand factor (vWF) to platelet glycoprotein Ib (GPIb), resulting in… 
Highly Cited
1986
Highly Cited
1986
Proteolysis of platelet glycoprotein Ib by plasmin is facilitated by plasmin lysine-binding regions.
We have characterized the effects of plasmin on glycoprotein Ib (GpIb), a platelet membrane receptor for von Willebrand factor… 
Highly Cited
1985
Highly Cited
1985
Localization of thrombospondin in clots formed in situ.
Thrombospondin is a principal glycoprotein secreted by thrombin-stimulated platelets and has known affinities for fibrinogen and… 
Highly Cited
1984
Highly Cited
1984
Inhibition of von Willebrand factor–platelet interaction by fibrinogen
The prolonged bleeding time and frequent haemorrhagic episodes in patients with severe von Willebrand's disease (vWD) attest to… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)