UGT1A7 gene

Known as: UDP Glucuronosyltransferase 1 Family, Polypeptide A7 Gene, UGT1G, UDP-GLYCOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A7 
This gene plays a role in detoxification.
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
PURPOSE UGT1A1*28 is considered the main pharmacogenetic predictor of the toxicity outcome of irinotecan-treated patients. We… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE To determine whether uridine diphosphate-glucuronosyltransferase 1A1, UGT1A7, and UGT1A9 polymorphisms affect the… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE Capecitabine and irinotecan are commonly used in the treatment of metastatic colorectal cancer (CRC). We hypothesized… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND & AIMS Chronic pancreatitis and pancreatic adenocarcinoma are associated with alcohol abuse, consumption of tobacco… (More)
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Highly Cited
2003
Highly Cited
2003
In vitro metabolic studies revealed that along with UDP-glucuronosyltransferase (UGT) 1A1, the hepatic UGT1A9 and the… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Genetic polymorphisms in the human UDP-glucuronosyltransferase-1A7 (UGT1A7) gene are detected and significantly… (More)
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Highly Cited
2002
Highly Cited
2002
7-Ethyl-10-hydroxycamptothecin (SN-38) is the pharmacologically active metabolite of irinotecan, in addition to being responsible… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND UDP-glucuronosyltransferase 1A7 (UGT1A7) detoxifies several tobacco carcinogens. We determined whether UGT1A7… (More)
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Highly Cited
2000
Highly Cited
2000
One of the most important mechanisms involved in host defense against xenobiotic chemicals and endogenous toxins is the… (More)
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Highly Cited
1997
Highly Cited
1997
Family 1 UDP-glucuronosyltransferases (UGTs) (UGT1A) are encoded by a locus that predicts the existence of at least nine… (More)
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