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UDP-Glucuronosyltransferase 1-7

Known as: UDP-Glucuronosyltransferase 1-G, UGT-1G, UGT1-07 
UDP-glucuronosyltransferase 1-7 (530 aa, ~60 kDa) is encoded by the human UGT1A7 gene. This protein is involved in the conjugation and elimination of… Expand
National Institutes of Health

Related topics

Related topics

13 relations
Carbohydrate MetabolismEnzyme GeneGastric TissueGlycosyltransferase Gene
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Papers overview

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Highly Cited
2010
Highly Cited
2010
Coffee induces expression of glucuronosyltransferases by the aryl hydrocarbon receptor and Nrf2 in liver and stomach.
BACKGROUND & AIMS Coffee is one of the most widely consumed beverages worldwide. Epidemiologic data indicate that coffee… Expand
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Highly Cited
2010
Highly Cited
2010
Phase II Metabolism of Hesperetin by Individual UDP-Glucuronosyltransferases and Sulfotransferases and Rat and Human Tissue Samples
Phase II metabolism by UDP-glucuronosyltransferases (UGTs) and sulfotransferases (SULTs) is the predominant metabolic pathway… Expand
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Highly Cited
2005
Highly Cited
2005
Hepatic Expression of the UGT1A9 Gene Is Governed by Hepatocyte Nuclear Factor 4α
UDP-glucuronosyltransferase (UGT) enzymes catalyze the glucuronidation reaction, which is a major pathway in the catabolism and… Expand
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Review
2004
Review
2004
Regulation of UDP glucuronosyltransferases in the gastrointestinal tract.
The UDP glucuronosyltransferases (UGT) of the gastrointestinal (GI) tract have a crucial role in protection against the toxic… Expand
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Highly Cited
2003
Highly Cited
2003
Novel Functional Polymorphisms in the UGT1A7 and UGT1A9 Glucuronidating Enzymes in Caucasian and African-American Subjects and Their Impact on the Metabolism of 7-Ethyl-10-hydroxycamptothecin and…
In vitro metabolic studies revealed that along with UDP-glucuronosyltransferase (UGT) 1A1, the hepatic UGT1A9 and the… Expand
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Highly Cited
2000
Highly Cited
2000
Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene.
One of the most important mechanisms involved in host defense against xenobiotic chemicals and endogenous toxins is the… Expand
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Highly Cited
2000
Highly Cited
2000
Distribution and inducibility by 3-methylcholanthrene of family 1 UDP-glucuronosyltransferases in the rat gastrointestinal tract.
UDP-Glucuronosyltransferases (UGT) catalyze the glucuronidation of a broad spectrum of endobiotic and xenobiotic substrates. The… Expand
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Highly Cited
1999
Highly Cited
1999
Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus.
7-Ethyl-10-hydroxycamptothecin (SN-38) is a very promising anticancer drug used for the treatment of metastatic colonrectal… Expand
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Highly Cited
1997
Highly Cited
1997
Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue.
Family 1 UDP-glucuronosyltransferases (UGTs) (UGT1A) are encoded by a locus that predicts the existence of at least nine… Expand
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Highly Cited
1994
Highly Cited
1994
Glucuronidation of carcinogenic arylamines and their N-hydroxy derivatives by rat and human phenol UDP-glucuronosyltransferase of the UGT1 gene complex.
Since carcinogenic arylamines are sequentially oxidized and conjugated with glucuronic acid, differences in glucuronidation may… Expand
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