UDP-Glucuronosyltransferase 1-7

Known as: UDP-Glucuronosyltransferase 1-G, UGT-1G, UGT1-07 
UDP-glucuronosyltransferase 1-7 (530 aa, ~60 kDa) is encoded by the human UGT1A7 gene. This protein is involved in the conjugation and elimination of… (More)
National Institutes of Health

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Carbohydrate MetabolismEnzyme GeneGastric TissueGlycosyltransferase Gene
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Papers overview

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2010
2010
Coffee induces expression of glucuronosyltransferases by the aryl hydrocarbon receptor and Nrf2 in liver and stomach.
BACKGROUND & AIMS Coffee is one of the most widely consumed beverages worldwide. Epidemiologic data indicate that coffee… (More)
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2005
2005
Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity.
UDP-glucuronosyltransferase (UGT) isozymes catalyze detoxification of numerous chemical toxins present in our daily diet and… (More)
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Review
2004
Review
2004
Regulation of UDP glucuronosyltransferases in the gastrointestinal tract.
The UDP glucuronosyltransferases (UGT) of the gastrointestinal (GI) tract have a crucial role in protection against the toxic… (More)
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Highly Cited
2003
Highly Cited
2003
Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and…
In vitro metabolic studies revealed that along with UDP-glucuronosyltransferase (UGT) 1A1, the hepatic UGT1A9 and the… (More)
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2001
2001
Glucuronidation of 1-hydroxypyrene by human liver microsomes and human UDP-glucuronosyltransferases UGT1A6, UGT1A7, and UGT1A9: development of a high-sensitivity glucuronidation assay for human…
Human UDP-glucuronosyltransferases (UGT, EC 2.4.1.17) involved in the biotransformation of pyrene were investigated by a… (More)
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Highly Cited
2000
Highly Cited
2000
Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene.
One of the most important mechanisms involved in host defense against xenobiotic chemicals and endogenous toxins is the… (More)
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1999
1999
Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus.
7-Ethyl-10-hydroxycamptothecin (SN-38) is a very promising anticancer drug used for the treatment of metastatic colonrectal… (More)
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1997
1997
Identification of a rat oltipraz-inducible UDP-glucuronosyltransferase (UGT1A7) with activity towards benzo(a)pyrene-7,8-dihydrodiol.
Previous work has shown that polycyclic aromatic hydrocarbons and oltipraz both induce an unidentified rat liver UDP… (More)
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Highly Cited
1997
Highly Cited
1997
Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue.
Family 1 UDP-glucuronosyltransferases (UGTs) (UGT1A) are encoded by a locus that predicts the existence of at least nine… (More)
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1994
1994
Glucuronidation of carcinogenic arylamines and their N-hydroxy derivatives by rat and human phenol UDP-glucuronosyltransferase of the UGT1 gene complex.
Since carcinogenic arylamines are sequentially oxidized and conjugated with glucuronic acid, differences in glucuronidation may… (More)
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