Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
- R. Tukey, C. Strassburg
- BiologyAnnual Review of Pharmacology and Toxicology
- 2000
Characterization of the UGT1A locus and genetic studies directed at understanding the role of bilirubin glucuronidation and the biochemical basis of the clinical symptoms found in unconjugated hyperbilirubinemia have uncovered the structural gene polymorphisms associated with Crigler-Najjar's and Gilbert's syndrome.
Treatment options in patients with chylothorax.
- H. Schild, C. Strassburg, A. Welz, J. Kalff
- MedicineDeutsches Ärzteblatt International
- 29 November 2013
Interventional radiological procedures have now taken their place alongside conservative treatment and surgery in the management of chylothorax, although they are currently available in only a small number of centers.
Developmental aspects of human hepatic drug glucuronidation in young children and adults
- C. Strassburg, A. Strassburg, M. Manns
- Medicine, BiologyGut
- 1 February 2002
The differential regulation of UGT1A9 and UGT2B4 expression extends beyond two years of age and is capable of influencing hepatic glucuronidation of common therapeutic drugs in children.
Expression of the UDP-glucuronosyltransferase 1A Locus in Human Colon
- C. Strassburg, M. Manns, R. Tukey
- BiologyJournal of Biological Chemistry
- 10 April 1998
The highly related human UGT1A7–1A10 cluster is expressed in a tissue-specific fashion and underlines the role and diversity of physiological glucuronidation at the distal end of the digestive tract.
Polymorphic Gene Regulation and Interindividual Variation of UDP-glucuronosyltransferase Activity in Human Small Intestine*
- C. Strassburg, S. Kneip, M. Manns
- BiologyJournal of Biological Chemistry
- 17 November 2000
Tissue-specific and interindividual polymorphic regulation of UGT1A and UGT2B genes in small intestine is identified and implicated as molecular biological determinant contributing to interindividual prehepatic drug and xenobiotic metabolism in humans.
Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP‐glucuronosyltransferase UGT1A4
- U. Ehmer, A. Vogel, Jan-Karl Schütte, Britta Krone, M. Manns, C. Strassburg
- Biology, MedicineHepatology
- 1 April 2004
Two polymorphisms of the hepatic UGT1A4 protein show a differential metabolic activity toward mutagenic amines and endogenous steroids, altering hepatic metabolism and detoxification.
Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer
- C. Strassburg, A. Vogel, S. Kneip, R. Tukey, M. Manns
- Biology, MedicineGut
- 1 June 2002
A potential novel risk factor in sporadic colorectal cancer which may contribute to the identification of risk groups and to the elucidation of factors involved in colon carcinogenesis is identified.
Budesonide induces remission more effectively than prednisone in a controlled trial of patients with autoimmune hepatitis.
- M. Manns, M. Woynarowski, C. Strassburg
- Medicine, BiologyGastroenterology
- 1 October 2010
Oral budesonide, in combination with azathioprine, induces and maintains remission in patients with noncirrhotic AIH, with a low rate of steroid-specific side effects.
Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract.
- R. Tukey, C. Strassburg
- BiologyMolecular Pharmacology
- 1 March 2001
Recent findings that highlight the genetic multiplicity and regulatory patterns of the phase II superfamily UDP-glucuronosyltransferases (UGTs) are focused on.
Glucuronide and glucoside conjugation of mycophenolic acid by human liver, kidney and intestinal microsomes
- M. Shipkova, C. Strassburg, E. Wieland
- BiologyBritish Journal of Pharmacology
- 1 March 2001
Investigations of the formation of these metabolites by human liver, kidney, and intestinal microsomes, as well as by recombinant UDP‐glucuronosyltransferases show extrahepatic tissues particularly the kidney may play a significant role in the overall biotransformation of MPA in man.
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