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UCHL1 gene

Known as: UCHL1, ubiquitin thiolesterase, Uch-L1 
This gene plays a role in the metabolism of ubiquitinated proteins.
National Institutes of Health

Related topics

Related topics

7 relations
CD45RO AntigensDeubiquitinationHydrolysisProteolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
High glucose-induced apoptosis and necroptosis in podocytes is regulated by UCHL1 via RIPK1/RIPK3 pathway.
2017
2017
cPKCγ‐mediated down‐regulation of UCHL1 alleviates ischaemic neuronal injuries by decreasing autophagy via ERK‐mTOR pathway
Stroke is one of the leading causes of death in the world, but its underlying mechanisms remain unclear. Both conventional… 
Highly Cited
2014
Highly Cited
2014
UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells
The islet in type 2 diabetes mellitus (T2DM) is characterized by a deficit in β-cells and increased β-cell apoptosis attributable… 
2014
2014
Silencing of UCHL1 by CpG Promoter Hyper-methylation is Associated with Metastatic Gastroenteropancreatic Well-Differentiated Neuroendocrine (Carcinoid) Tumors
BackgroundWell-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare tumors with varying metastatic… 
Highly Cited
2008
Highly Cited
2008
The role of PGP9.5 as a tumor suppressor gene in human cancer
PGP9.5 is a controversial molecule from an oncologic point of view. We recently identified frequent methylation of PGP9.5 gene… 
2006
2006
Case–control study of UCHL1 S18Y variant in Parkinson's disease
A recent meta‐analysis observed a greater significant inverse association of the ubiquitin carboxy‐terminal hydrolase L1 (UCHL1… 
1991
1991
Leu-22 (L60). A more sensitive marker than UCHL1 for peripheral T-cell lymphomas, particularly large-cell types.
Paraffin-embedded sections of 77 peripheral T-cell lymphomas (PTCLs) were stained with several monoclonal antibodies, including… 
1989
1989
Use of monoclonal antibodies (UCHL1, Ki-B3) against T and B cell antigens in routine paraffin-embedded skin biopsy specimens.
Highly Cited
1988
Highly Cited
1988
Limiting dilution analysis of proliferative responses in human lymphocyte populations defined by the monoclonal antibody UCHL1: implications for differential CD45 expression in T cell memory…
Using limiting dilution analysis, we investigated proliferative responses of UCHL1+ and UCHL1− T cell populations to compare the… 
Highly Cited
1988
Highly Cited
1988
The monoclonal antibody, UCHL1, recognizes a 180,000 MW component of the human leucocyte-common antigen, CD45.
The leucocyte-common antigen (L-CA or CD45) is a family of high molecular weight glycoproteins, ranging from 180,000 to 220,000… 
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