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UC 781

Known as: UC-781, UC781 
National Institutes of Health

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2 relations

Broader (2)

AnilidesFurans

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Rectal microbicide development
Purpose of reviewIndividuals practicing unprotected receptive anal intercourse are at particularly high risk of HIV infection… 
Review
2012
Review
2012
Reverse transcriptase inhibitors as microbicides.
The CAPRISA 004 study in South Africa has accelerated the development of vaginal and rectal microbicides containing… 
2011
2011
Ethylene vinyl acetate intravaginal rings for the simultaneous delivery of the antiretroviral UC781 and contraceptive levonorgestrel
Ethylene vinyl acetate intravaginal rings (IVRs) were prepared by hot-melt compounding and injection moulding. The IVRs contained… 
Review
2010
Review
2010
Microbicide research: current and future directions
Purpose of reviewMicrobicide research has been in the forefront of scientific literature in recent months. Results of large-scale… 
Highly Cited
2007
Highly Cited
2007
Preclinical Safety Assessments of UC781 Anti-Human Immunodeficiency Virus Topical Microbicide Formulations
ABSTRACT The nonnucleoside reverse transcriptase inhibitor UC781 is under development as a potential microbicide to prevent… 
2006
2006
In Vitro Microbicidal Activity of the Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI) UC781 against NNRTI-Resistant Human Immunodeficiency Virus Type 1
ABSTRACT The nonnucleoside reverse transcriptase inhibitor (NNRTI) UC781 is under development as a microbicide to prevent sexual… 
Highly Cited
2003
Highly Cited
2003
Blocking of cell-free and cell-associated HIV-1 transmission through human cervix organ culture with UC781
Objective: To determine the efficacy of UC781 in preventing HIV-1 transmission through cervical tissue. Design: Use of human… 
2002
2002
Attenuated infectivity of HIV type 1 from epithelial cells pretreated with a tight-binding nonnucleoside reverse transcriptase inhibitor.
Short exposure of uninfected lymphocytes to UC781, a tight-binding nonnucleoside reverse transcriptase inhibitor (NNRTI), renders… 
Highly Cited
1998
Highly Cited
1998
Preclinical studies on thiocarboxanilide UC‐781 as a virucidal agent
Background:Thiocarboxanilide UC-781 is a highly potent and selective nonnucleoside reverse transcriptase inhibitor (NNRTI) of HIV… 
1997
1997
Efficacy, pharmacokinetics, and in vivo antiviral activity of UC781, a highly potent, orally bioavailable nonnucleoside reverse transcriptase inhibitor of HIV type 1.
A series of compounds related to oxathiin carboxanilide has been identified as nonnucleoside reverse transcriptase inhibitors… 
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