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UBE2N gene

Known as: ubiquitin conjugating enzyme E2 N, MGC8489, UBIQUITIN-CONJUGATING ENZYME E2N 
This gene plays a role in polyubiquitination.
National Institutes of Health

Related topics

Related topics

6 relations
DNA RepairPolyubiquitinationSignal Transduction InductionUBE2N protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Legionella pneumophila balances ubiquitin transglutamination
The effector MavC of the bacterial pathogen Legionella pneumophila catalyzes a noncanonical ubiquitination of the host ubiquitin… 
2020
2020
Insights into catalysis and regulation of non-canonical ubiquitination and deubiquitination by bacterial deamidase effectors
The bacterial effector MavC catalyzes non-canonical ubiquitination of host E2 enzyme UBE2N without engaging any of the… 
2018
2018
Structural insights into the nanomolar affinity of RING E3 ligase ZNRF1 for Ube2N and its functional implications
RING (Really Interesting New Gene) domains in ubiquitin RING E3 ligases exclusively engage ubiquitin (Ub)-loaded E2s to… 
2016
2016
Inhibition of UBE2N As a Therapeutic Approach in Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML)
Hematopoietic stem and progenitor cells (HSPC) from MDS and AML patients exhibit overexpression of TRAF6 and related innate… 
2013
2013
Comprehensive Analysis of miRNA Targets in Breast Cancer Cells *
miRNAs regulate mRNA stability and translation through the action of the RNAiinduced silencing complex. In this study, we… 
2012
2012
Comparative proteomic analysis of colon cancer cell HCT-15 in response to all-trans retinoic acid treatment.
Colon cancer is one of the most common malignances. In vitro and in vivo study show that retinoic acids inhibit a wide variety of… 
2012
2012
Analysis of binary interactions between OTUB1 and E2 ubiquitin-conjugating enzymes
Post-translational modification of proteins via ubiquitination is mediated by three enzyme families; E1 activating enzymes, E2… 
2010
2010
Cell-free-based protein microarray technology using agarose/DNA microplate.
Protein microarray is considered to be one of the key analytical tools for high-throughput protein function analysis. We found… 
2009
2009
Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells.
2003
2003
Genetics: Locating low-penetrance genes
Mutations in high-penetrance genes — such as BRCA1 and BRCA2 — do not directly cause cancer but greatly increase the chance of it… 
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