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U63A05

National Institutes of Health

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ImidazolesIsoquinolines

Papers overview

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2011
2011
A novel imidazo[1,5-b]isoquinolinone derivative, U63A05, inhibits Syk activation in mast cells to suppress IgE-mediated anaphylaxis in mice.
Mast cells play a pivotal role in IgE-mediated allergic responses. Development of specific inhibitors against FcεRI-associated… 
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