A novel imidazo[1,5-b]isoquinolinone derivative, U63A05, inhibits Syk activation in mast cells to suppress IgE-mediated anaphylaxis in mice.

@article{Kim2011ANI,
  title={A novel imidazo[1,5-b]isoquinolinone derivative, U63A05, inhibits Syk activation in mast cells to suppress IgE-mediated anaphylaxis in mice.},
  author={Do Kyun Kim and Jun Ho Lee and Jie Wan Kim and Hyuk Soon Kim and A-Ram Kim and Bo Kyung Kim and Kyu Yang Yi and Hye-Jin Park and D. K. Park and Wahn Soo Choi},
  journal={Journal of pharmacological sciences},
  year={2011},
  volume={115 4},
  pages={
          500-8
        }
}
Mast cells play a pivotal role in IgE-mediated allergic responses. Development of specific inhibitors against FcεRI-associated proximal signaling molecules in mast cells may represent a promising therapeutic strategy for allergic diseases. We examined whether a novel synthetic compound, 3-butyl-1-chloro-8-(2-methoxycarbonyl)phenyl-5H-imidazo[1,5-b]isoquinolin-10-one (U63A05), could suppress antigen-stimulated degranulation and cytokine secretion in mast cells and IgE-mediated passive cutaneous… CONTINUE READING

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