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Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway.
This study suggests that the suppression of M MP-1 and MMP-3 production by curcumin in CIA is mediated through the inhibition of PKCdelta and the JNK/c-Jun signaling pathway.
Interleukin-33 stimulates formation of functional osteoclasts from human CD14+ monocytes
  • S. Mun, N. Ko, +11 authors W. Choi
  • Biology, Medicine
    Cellular and Molecular Life Sciences
  • 8 June 2010
This study suggests that the osteoclastogenic property of IL-33 is mediated through TRAF6 as well as the immunoreceptor tyrosine-based activation motif-dependent Syk/PLCγ pathway in human CD14+ monocytes.
Morus bombycis Koidzumi extract suppresses collagen-induced arthritis by inhibiting the activation of nuclear factor-κB and activator protein-1 in mice.
MB produced an anti-arthritis effect in CIA mice by inhibiting the production of critical inflammatory mediators and osteoclasts through the downregulation of NF-κB and AP-1.
Tumor necrosis factor alpha-induced interleukin-32 is positively regulated via the Syk/protein kinase Cdelta/JNK pathway in rheumatoid synovial fibroblasts.
The present findings suggest that IL-32 may be a newly identified prognostic biomarker in RA, thereby adding valuable knowledge to the understanding of this disease.
The Src Family Kinase Fgr Is Critical for Activation of Mast Cells and IgE-Mediated Anaphylaxis in Mice
The role of Fgr is defined to positively regulates mast cell through activation of Syk and the interplay among Src family kinases is clarified to identify Fgr as a potential therapeutic target for allergic diseases.
Mesenteric IL-10-producing CD5+ regulatory B cells suppress cow’s milk casein-induced allergic responses in mice
Taken together, mesenteric IL-10-producing regulatory B cells control food allergy via Foxp3+ regulatory T cells and could potentially act as a therapeutic regulator for food allergy.
DJ-1 regulates mast cell activation and IgE-mediated allergic responses.
BACKGROUND DJ-1 is an antioxidant protein known to reduce levels of reactive oxygen species (ROS), but its presence or function in mast cells and allergic diseases is unknown. OBJECTIVES We sought
The Scaffold Protein Prohibitin Is Required for Antigen-Stimulated Signaling in Mast Cells
It is suggested that PHB is essential for FcεRI-mediated mast cell activation and allergic responses in vivo, raising the possibility thatPHB might serve as a therapeutic target for the treatment of allergic diseases.
Identification of H-Ras-specific motif for the activation of invasive signaling program in human breast epithelial cells.
Light is shed on the structural basis for the Ras isoform-specific invasive program of breast epithelial cells, providing information for the development of agents that specifically target invasion-related H-Ras pathways in human cancer.
Interleukin-10–producing CD5+ B cells inhibit mast cells during immunoglobulin E–mediated allergic responses
It is found that IL-10–producing CD5+ B cells suppressed the immunoglobulin E (IgE)– and antigen-mediated activation of mast cells in vitro as well as allergic responses in mice in an IL- 10–dependent manner.