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U 69593
Known as:
Benzeneacetamide, N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-, (5alpha,7alpha,8beta)-(-)-
, U-69593
National Institutes of Health
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Related topics
Related topics
4 relations
Broader (4)
Analgesics
Benzeneacetamides
Diuretics
Pyrrolidines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats
S. Mague
,
Andrea M. Pliakas
,
+6 authors
W. Carlezon
Journal of Pharmacology and Experimental…
2003
Corpus ID: 7235990
We showed previously that cAMP response element-binding protein (CREB) within the nucleus accumbens (NAc) of rats regulates…
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Highly Cited
2003
Highly Cited
2003
Effects of κ-opioid receptor ligands on intracranial self-stimulation in rats
M. Todtenkopf
,
J. Marcus
,
P. Portoghese
,
W. Carlezon
Psychopharmacology
2003
Corpus ID: 35578614
RationaleElevations in cAMP response element binding protein (CREB) function within the mesolimbic system of rats reduce cocaine…
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Highly Cited
2003
Highly Cited
2003
Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats.
S. Mague
,
Andrea M. Pliakas
,
+6 authors
W. Carlezon
The Journal of pharmacology and experimental…
2003
Corpus ID: 6523011
We showed previously that cAMP response element-binding protein (CREB) within the nucleus accumbens (NAc) of rats regulates…
Expand
Highly Cited
2000
Highly Cited
2000
κ-Opioid Receptor Activation Modifies Dopamine Uptake in the Nucleus Accumbens and Opposes the Effects of Cocaine
A. C. Thompson
,
A. Zapata
,
J. B. Justice
,
R. Vaughan
,
L. Sharpe
,
T. Shippenberg
The Journal of Neuroscience
2000
Corpus ID: 13303684
Coadministration of κ-opioid receptor agonists (κ-agonists) with cocaine prevents alterations in dialysate dopamine (DA…
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Highly Cited
1999
Highly Cited
1999
The K‐Opioid Agonist, U‐69593, Decreases Acute Amphetamine‐Evoked Behaviors and Calcium‐Dependent Dialysate Levels of Dopamine and Glutamate in the Ventral Striatum
A. Gray
,
S. Rawls
,
T. Shippenberg
,
J. McGinty
Journal of neurochemistry
1999
Corpus ID: 1261766
Abstract : The effect of a k‐opioid receptor agonist on acute amphetamine‐induced behavioral activation and dialysate levels of…
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1998
1998
Repeated treatment with the selective kappa opioid agonist U‐69593 produces a marked depletion of dopamine D2 receptors
S. Izenwasser
,
J. Acri
,
P. Kunko
,
T. Shippenberg
Synapse
1998
Corpus ID: 21964032
U‐69593, the selective κ‐opioid agonist, was repeatedly administered in single daily injections (0.32 mg/kg) to male, Sprague…
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Highly Cited
1994
Highly Cited
1994
Opioids suppress spontaneous activity of polymodal nociceptors in rat paw skin induced by ultraviolet irradiation
N. Andreev
,
L. Urbán
,
A. Dray
Neuroscience
1994
Corpus ID: 23983355
Highly Cited
1994
Highly Cited
1994
U-69593 prevents cocaine sensitization by normalizing basal accumbens dopamine.
C. Heidbreder
,
T. Shippenberg
Neuroreport
1994
Corpus ID: 40163924
Repeated intermittent administration of cocaine (20 mg kg-1, i.p.) for 3 days dramatically increased basal dopamine (DA) overflow…
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Highly Cited
1993
Highly Cited
1993
Examination of the neurochemical substrates mediating the motivational effects of opioids: role of the mesolimbic dopamine system and D-1 vs. D-2 dopamine receptors.
T. Shippenberg
,
R. Bals-Kubik
,
A. Herz
The Journal of pharmacology and experimental…
1993
Corpus ID: 46250024
Both the reinforcing and aversive effects of exogenous opioids have been attributed to the activation of opioid receptors within…
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1993
1993
Opioid receptor regulation of 5-hydroxytryptamine release from the rat hippocampus measured by in vivo microdialysis
M. Yoshioka
,
M. Matsumoto
,
H. Togashi
,
Charles B. Smith
,
H. Saito
Brain Research
1993
Corpus ID: 1556815
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