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U 69593

Known as: Benzeneacetamide, N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4.5)dec-8-yl)-, (5alpha,7alpha,8beta)-(-)-, U-69593 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (4)

AnalgesicsBenzeneacetamidesDiureticsPyrrolidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats
We showed previously that cAMP response element-binding protein (CREB) within the nucleus accumbens (NAc) of rats regulates… 
Highly Cited
2003
Highly Cited
2003
Effects of κ-opioid receptor ligands on intracranial self-stimulation in rats
RationaleElevations in cAMP response element binding protein (CREB) function within the mesolimbic system of rats reduce cocaine… 
Highly Cited
2003
Highly Cited
2003
Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats.
We showed previously that cAMP response element-binding protein (CREB) within the nucleus accumbens (NAc) of rats regulates… 
Highly Cited
2000
Highly Cited
2000
κ-Opioid Receptor Activation Modifies Dopamine Uptake in the Nucleus Accumbens and Opposes the Effects of Cocaine
Coadministration of κ-opioid receptor agonists (κ-agonists) with cocaine prevents alterations in dialysate dopamine (DA… 
Highly Cited
1999
Highly Cited
1999
The K‐Opioid Agonist, U‐69593, Decreases Acute Amphetamine‐Evoked Behaviors and Calcium‐Dependent Dialysate Levels of Dopamine and Glutamate in the Ventral Striatum
Abstract : The effect of a k‐opioid receptor agonist on acute amphetamine‐induced behavioral activation and dialysate levels of… 
1998
1998
Repeated treatment with the selective kappa opioid agonist U‐69593 produces a marked depletion of dopamine D2 receptors
U‐69593, the selective κ‐opioid agonist, was repeatedly administered in single daily injections (0.32 mg/kg) to male, Sprague… 
Highly Cited
1994
Highly Cited
1994
Opioids suppress spontaneous activity of polymodal nociceptors in rat paw skin induced by ultraviolet irradiation
Highly Cited
1994
Highly Cited
1994
U-69593 prevents cocaine sensitization by normalizing basal accumbens dopamine.
Repeated intermittent administration of cocaine (20 mg kg-1, i.p.) for 3 days dramatically increased basal dopamine (DA) overflow… 
Highly Cited
1993
Highly Cited
1993
Examination of the neurochemical substrates mediating the motivational effects of opioids: role of the mesolimbic dopamine system and D-1 vs. D-2 dopamine receptors.
Both the reinforcing and aversive effects of exogenous opioids have been attributed to the activation of opioid receptors within… 
1993
1993
Opioid receptor regulation of 5-hydroxytryptamine release from the rat hippocampus measured by in vivo microdialysis
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