U 69593

Opioid receptors display basal signaling (constitutive, agonist-independent activity), which seems to be regulated by agonist… Expand

We showed previously that cAMP response element-binding protein (CREB) within the nucleus accumbens (NAc) of rats regulates… Expand

RationaleElevations in cAMP response element binding protein (CREB) function within the mesolimbic system of rats reduce cocaine… Expand

Coadministration of κ-opioid receptor agonists (κ-agonists) with cocaine prevents alterations in dialysate dopamine (DA… Expand

Abstract : The effect of a k‐opioid receptor agonist on acute amphetamine‐induced behavioral activation and dialysate levels of… Expand

U‐69593, the selective κ‐opioid agonist, was repeatedly administered in single daily injections (0.32 mg/kg) to male, Sprague… Expand

Xenopus oocytes expressed kappa-opioid specific binding sites after injection of cRNA prepared from a clone of the rat kappa… Expand

Repeated intermittent administration of cocaine (20 mg kg-1, i.p.) for 3 days dramatically increased basal dopamine (DA) overflow… Expand

Both the reinforcing and aversive effects of exogenous opioids have been attributed to the activation of opioid receptors within… Expand

The effects of treatment with the selective kappa-opioid receptor agonist U-69593 upon cocaine-induced changes in locomotor… Expand