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U 100766

Known as: PNU-100766, PNU100766, PNU 100766 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

linezolid

Papers overview

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Review
2003
Review
2003
Linezolid: The First Oxazolidinone Antimicrobial
Each antimicrobial agent developed for clinical use during the past 60 years has ultimately encountered problems with the… 
Highly Cited
2002
Highly Cited
2002
Cerebrospinal Fluid Linezolid Concentrations in Postneurosurgical Central Nervous System Infections
Gram-positive (GP) cocci, mainly methicillin-resistant staphylococci, are the most frequent pathogens involved in central nervous… 
Highly Cited
2001
Highly Cited
2001
Linezolid (PNU-100766) versus vancomycin in the treatment of hospitalized patients with nosocomial pneumonia: a randomized, double-blind, multicenter study.
Linezolid, the first oxazolidinone, is active against gram-positive bacteria, including multidrug-resistant strains. This… 
Highly Cited
2000
Highly Cited
2000
Randomized Comparison of Linezolid (PNU-100766) versus Oxacillin-Dicloxacillin for Treatment of Complicated Skin and Soft Tissue Infections
ABSTRACT This randomized, double-blind, multicenter trial compared the efficacy and safety of linezolid, an oxazolidinone, with… 
Highly Cited
1998
Highly Cited
1998
The in-vitro activity of linezolid (U-100766) and tentative breakpoints.
The in-vitro activity of linezolid, a novel oxazolidinone, was investigated in comparison with those of amoxycillin, cefuroxime… 
Highly Cited
1998
Highly Cited
1998
Comparative In Vitro Activities and Postantibiotic Effects of the Oxazolidinone Compounds Eperezolid (PNU-100592) and Linezolid (PNU-100766) versus Vancomycin against Staphylococcus aureus, Coagulase…
ABSTRACT The activities of the oxazolidinone antibacterial agents eperezolid (PNU-100592) and linezolid (PNU-100766) were… 
Highly Cited
1996
Highly Cited
1996
Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections.
Bacterial resistance development has become a very serious clinical problem for many classes of antibiotics. The 3-aryl-2… 
Highly Cited
1996
Highly Cited
1996
In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents
Oxazolidinones make up a relatively new class of antimicrobial agents which possess a unique mechanism of bacterial protein… 
Highly Cited
1996
Highly Cited
1996
In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections
The Upjohn oxazolidinones, U-100592 and U-100766, are orally bioavailable synthetic antimicrobial agents with spectra of activity… 
Highly Cited
1996
Highly Cited
1996
In vitro activities of oxazolidinone compounds U100592 and U100766 against Staphylococcus aureus and Staphylococcus epidermidis
The new oxazolidinone antimicrobial agents U100592 and U100766 demonstrated good in vitro inhibitory activity against clinical… 
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