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U 100766
Known as:
PNU-100766
, PNU100766
, PNU 100766
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National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
linezolid
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2003
Review
2003
Linezolid: The First Oxazolidinone Antimicrobial
R. Moellering
Annals of Internal Medicine
2003
Corpus ID: 23689046
Each antimicrobial agent developed for clinical use during the past 60 years has ultimately encountered problems with the…
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Highly Cited
2002
Highly Cited
2002
Cerebrospinal Fluid Linezolid Concentrations in Postneurosurgical Central Nervous System Infections
P. Villani
,
M. B. Regazzi
,
+6 authors
R. Bergomi
Antimicrobial Agents and Chemotherapy
2002
Corpus ID: 35201474
Gram-positive (GP) cocci, mainly methicillin-resistant staphylococci, are the most frequent pathogens involved in central nervous…
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Highly Cited
2001
Highly Cited
2001
Linezolid (PNU-100766) versus vancomycin in the treatment of hospitalized patients with nosocomial pneumonia: a randomized, double-blind, multicenter study.
E. Rubinstein
,
S. Cammarata
,
T. Oliphant
,
R. Wunderink
Clinical infectious diseases : an official…
2001
Corpus ID: 23471659
Linezolid, the first oxazolidinone, is active against gram-positive bacteria, including multidrug-resistant strains. This…
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Highly Cited
2000
Highly Cited
2000
Randomized Comparison of Linezolid (PNU-100766) versus Oxacillin-Dicloxacillin for Treatment of Complicated Skin and Soft Tissue Infections
D. Stevens
,
Leon G. Smith
,
+4 authors
B. Hafkin
Antimicrobial Agents and Chemotherapy
2000
Corpus ID: 21922973
ABSTRACT This randomized, double-blind, multicenter trial compared the efficacy and safety of linezolid, an oxazolidinone, with…
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Highly Cited
1998
Highly Cited
1998
The in-vitro activity of linezolid (U-100766) and tentative breakpoints.
R. Wise
,
J. Andrews
,
F. Boswell
,
J. Ashby
The Journal of antimicrobial chemotherapy
1998
Corpus ID: 20859372
The in-vitro activity of linezolid, a novel oxazolidinone, was investigated in comparison with those of amoxycillin, cefuroxime…
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Highly Cited
1998
Highly Cited
1998
Comparative In Vitro Activities and Postantibiotic Effects of the Oxazolidinone Compounds Eperezolid (PNU-100592) and Linezolid (PNU-100766) versus Vancomycin against Staphylococcus aureus, Coagulase…
Michael J. Rybak
,
D. Cappelletty
,
Tabitha Moldovan
,
J. Aeschlimann
,
G. Kaatz
Antimicrobial Agents and Chemotherapy
1998
Corpus ID: 38862245
ABSTRACT The activities of the oxazolidinone antibacterial agents eperezolid (PNU-100592) and linezolid (PNU-100766) were…
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Highly Cited
1996
Highly Cited
1996
Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections.
S. J. Brickner
,
D. Hutchinson
,
+8 authors
G. Zurenko
Journal of medicinal chemistry
1996
Corpus ID: 11513793
Bacterial resistance development has become a very serious clinical problem for many classes of antibiotics. The 3-aryl-2…
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Highly Cited
1996
Highly Cited
1996
In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents
G. Zurenko
,
B. Yagi
,
+6 authors
S. J. Brickner
Antimicrobial agents and chemotherapy
1996
Corpus ID: 19798089
Oxazolidinones make up a relatively new class of antimicrobial agents which possess a unique mechanism of bacterial protein…
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Highly Cited
1996
Highly Cited
1996
In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections
C. W. Ford
,
J. C. Hamel
,
+6 authors
S. J. Brickner
Antimicrobial agents and chemotherapy
1996
Corpus ID: 206715727
The Upjohn oxazolidinones, U-100592 and U-100766, are orally bioavailable synthetic antimicrobial agents with spectra of activity…
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Highly Cited
1996
Highly Cited
1996
In vitro activities of oxazolidinone compounds U100592 and U100766 against Staphylococcus aureus and Staphylococcus epidermidis
G. Kaatz
,
S. M. Seo
Antimicrobial agents and chemotherapy
1996
Corpus ID: 44864756
The new oxazolidinone antimicrobial agents U100592 and U100766 demonstrated good in vitro inhibitory activity against clinical…
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