In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents
- G. Zurenko, B. Yagi, S. J. Brickner
- Medicine, BiologyAntimicrobial Agents and Chemotherapy
- 1 April 1996
Time-kill studies demonstrated a bacteriostatic effect of the analogs against staphylococci and enterococci but a bactericidal effect against streptococci.
Tedizolid for the management of human infections: in vitro characteristics.
- Jeffrey B Locke, G. Zurenko, K. Shaw, K. Bartizal
- Biology, MedicineClinical Infectious Diseases
- 2014
The greater potency and improved resistance profile of tedizolid provides the microbiologic basis for considering this molecule as an alternative to linezolid for the treatment of serious infections caused by Gram-positive pathogens.
Besifloxacin, a Novel Fluoroquinolone, Has Broad-Spectrum In Vitro Activity against Aerobic and Anaerobic Bacteria
- W. Haas, C. Pillar, G. Zurenko, Jacqueline C. Lee, L. Brunner, T. Morris
- Medicine, BiologyAntimicrobial Agents and Chemotherapy
- 8 June 2009
Besifloxacin demonstrated potent, broad-spectrum activity, which was particularly notable against gram-positive and gram-negative isolates that were resistant to other fluoroquinolones and classes of antibacterial agents.
In Vitro Activity of TR-700, the Active Ingredient of the Antibacterial Prodrug TR-701, a Novel Oxazolidinone Antibacterial Agent
- R. Schaadt, Debora Sweeney, D. Shinabarger, G. Zurenko
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 15 June 2009
In vitro results indicate that TR-700 is a promising new oxazolidinone antibacterial agent with greater in vitro potency than linezolid against clinically important gram-positive bacteria.
In Vitro Activity of TR-700, the Antibacterial Moiety of the Prodrug TR-701, against Linezolid-Resistant Strains
- K. Shaw, S. Poppe, G. Zurenko
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 6 October 2008
In this study evaluating the in vitro sensitivity of LZD-resistant isolates, TR-700 demonstrated 8- to 16-fold-greater potency than LD against all strains tested, including methicillin-resistant Staphylococcus aureus (MRSA), strains of MRSA carrying the mobile cfr methyltransferase gene, and vancomycin-resistant enterococci.
Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections.
- S. J. Brickner, D. Hutchinson, G. Zurenko
- Biology, ChemistryJournal of Medicinal Chemistry
- 2 February 1996
A novel and practical asymmetric synthesis of (5S)-(acetamidomethyl)-2-oxazolidinones has been developed and is employed for the synthesis of U-100592 and U-100766, which demonstrate potent in vitro activity against Mycobacterium tuberculosis.
Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity.
- M. R. Barbachyn, D. Hutchinson, G. Zurenko
- Biology, MedicineJournal of Medicinal Chemistry
- 2 February 1996
Consideration of these factors, along with a favorable pharmaco-kinetic and chronic toxicity profile in rats, suggests that 6 (U-100480) is a promising antimycobacterial agent.
Marine natural products as sources of antiviral, antimicrobial, and antineoplastic agents
- K. Rinehart, P. Shaw, Judith L. Connor
- Chemistry
- 1 January 1981
Abstract
In Vitro Activities of Linezolid Combined with Other Antimicrobial Agents against Staphylococci, Enterococci, Pneumococci, and Selected Gram-Negative Organisms
- M. T. Sweeney, G. Zurenko
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 1 June 2003
Overall, the in vitro data demonstrated that linezolid combined with other antimicrobial agents primarily produces an indifferent response, with infrequent occurrences of synergism and antagonism.
Substituent effects on the antibacterial activity of nitrogen-carbon-linked (azolylphenyl)oxazolidinones with expanded activity against the fastidious gram-negative organisms Haemophilus influenzae…
- M. Genin, D. A. Allwine, B. Yagi
- Chemistry, BiologyJournal of Medicinal Chemistry
- 17 February 2000
A series of new nitrogen-carbon-linked (azolylphenyl)oxazolidinone antibacterial agents has been prepared in an effort to expand the spectrum of activity of this class of antibiotics to include…
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