Tumor Initiation

The first stage of tumor induction by a carcinogen, consisting of subtle alteration of cells by exposure to a carcinogenic agent so that they are… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Chromatin and associated epigenetic mechanisms stabilize gene expression and cellular states while also facilitating appropriate… (More)
Is this relevant?
Review
2017
Review
2017
The intracellular calcium ions (Ca2+) act as second messenger to regulate gene transcription, cell proliferation, migration and… (More)
  • figure 1
  • table 1
  • table 2
Is this relevant?
Review
2010
Review
2010
There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2010
Highly Cited
2010
As the result of genetic alterations and tumor hypoxia, many cancer cells avidly take up glucose and generate lactate through… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Previous studies have suggested that the HIF transcription factors can both activate and inhibit gene expression. Here we show… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2008
Highly Cited
2008
BACKGROUND Mammographically dense breast tissue is one of the greatest risk factors for developing breast carcinoma. Despite the… (More)
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Adult cancers may derive from stem or early progenitor cells. Epigenetic modulation of gene expression is essential for normal… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Perforin (pfp) and interferon-gamma (IFN-gamma) together in C57BL/6 (B6) and BALB/c mouse strains provided optimal protection in… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Review
1996
Review
1996
that demonstrated tight linkage of the disease to markers on chromosome 5q21 (Bodmer et al., 1987; Leppert *The Johns Hopkins… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1993
Highly Cited
1993
Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been… (More)
Is this relevant?