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- Publications
- Influence
The structure of an antigenic determinant in a protein
- I. Wilson, H. Niman, R. Houghten, A. Cherenson, R. Lerner
- Biology, Medicine
- Cell
- 1 July 1984
The immunogenic and antigenic determinants of a synthetic peptide and the corresponding antigenic determinants in the parent protein have been elucidated. Four determinants have been defined by… Expand
General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.
- R. Houghten
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 August 1985
A novel yet simple method is described that facilitates the synthesis of large numbers of peptides to the extent that the synthesis process need no longer be the limiting factor in many studies… Expand
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.
- A. Schimmer, K. Welsh, +15 authors John Calvin Reed
- Biology, Medicine
- Cancer cell
- 2004
Apoptosis resistance commonly occurs in cancers, preventing activation of Caspase family cell death proteases. XIAP is an endogenous inhibitor of Caspases overexpressed in many cancers. We developed… Expand
Mapping the Prion Protein Using Recombinant Antibodies
- R. Williamson, D. Peretz, +6 authors D. Burton
- Biology, Medicine
- Journal of Virology
- 1 November 1998
ABSTRACT The fundamental event in prion disease is thought to be the posttranslational conversion of the cellular prion protein (PrPC) into a pathogenic isoform (PrPSc). The occurrence of PrPC on the… Expand
Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence
- J. Bittle, R. Houghten, +5 authors F. Brown
- Biology, Medicine
- Nature
- 1 July 1982
Chemically synthesized peptides corresponding to two different regions of the VP1 polypeptide of foot-and-mouth disease virus (FMDV) produced high levels of serotype-specific virus neutralizing… Expand
A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform.
- D. Peretz, R. A. Williamson, +9 authors D. Burton
- Chemistry, Medicine
- Journal of molecular biology
- 31 October 1997
The scrapie prion protein (PrPSc) is formed from the cellular isoform (PrPC) by a post-translational process that involves a profound conformational change. Linear epitopes for recombinant antibody… Expand
Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.
- C. Dooley, C. Spaeth, +5 authors L. Toll
- Chemistry, Medicine
- The Journal of pharmacology and experimental…
- 1 November 1997
Fifteen hexapeptides having high affinity for the opioid-like receptor ORL1 were identified from a combinatorial library containing more than 52 million different hexapeptides. The five compounds… Expand
Induction of broadly cross-reactive cytotoxic T cells recognizing an HIV-1 envelope determinant.
- H. Takahashi, Y. Nakagawa, +4 authors J. Berzofsky
- Biology, Medicine
- Science
- 17 January 1992
An immunodominant determinant for cytotoxic T lymphocytes (CTLs) exists in the hypervariable portion of human immunodeficiency virus-1 (HIV-1) gp160. Three mouse CTL lines (specific for isolates MN,… Expand
Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: immunodominant T-cell domains map to the polymorphic regions of the molecule.
- M. Good, D. Pombo, +6 authors L. Miller
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 1 February 1988
The definition of human T-cell antigenic sites is important for subunit vaccine development of a peptide immunogen if the goal is to allow antibody boosting during infection or to stimulate… Expand
Polyarginines Are Potent Furin Inhibitors*
- A. Cameron, J. Appel, R. Houghten, I. Lindberg
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 24 November 2000
The ubiquitous serine endoprotease furin has been implicated in the activation of bacterial toxins and viral glycoproteins as well as in the metastatic progression of certain tumors. Although high… Expand