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The structure of an antigenic determinant in a protein
View on Elsevier
General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.
  • R. Houghten
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences…
  • 1 August 1985
TLDR
Through examination of the binding of these analogs to monoclonal antibodies raised against residues 75-110 of HA1, it was found that a single amino acid, aspartic acid at position 101, is of unique importance to the interaction.
View on PubMed
Mapping the Prion Protein Using Recombinant Antibodies
TLDR
The rescue of a diverse panel of 19 PrP-specific recombinant monoclonal antibodies from phage display libraries prepared from PrP deficient mice immunized with infectious prions either in the form of rods or PrP 27-30 dispersed into liposomes is reported.
View on ASMUSA
Topology of the 32‐kd liver gap junction protein determined by site‐directed antibody localizations.
TLDR
Results indicate a transmembrane orientation for the protein with the amino and carboxyl termini located on the cytoplasmic side of the membrane and a model is proposed for the trans Membrane folding of the gap junction protein.
View on Wiley
Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence
Chemically synthesized peptides corresponding to two different regions of the VP1 polypeptide of foot-and-mouth disease virus (FMDV) produced high levels of serotype-specific virus neutralizing…
View on Nature
Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: immunodominant T-cell domains map to the polymorphic regions of the molecule.
  • M. Good, D. Pombo, L. Miller
  • Biology, Medicine
    Proceedings of the National Academy of Sciences…
  • 1 February 1988
TLDR
Three immunodominant domains were located outside the repetitive region of the CS protein, suggesting that parasite mutation and selection has occurred in response to immune pressure from T cells, and may impose an obstacle for vaccine development.
View on PubMed
Induction of broadly cross-reactive cytotoxic T cells recognizing an HIV-1 envelope determinant.
TLDR
CTL populations with broad specificities were generated by restimulation of IIIB-gp160 primed cells with MN-type peptides that have an aliphatic substitution at 325, representing an approach to synthetic vaccines that can generate broadly cross-reactive CTLs capable of effector function against a wide range of HIV isolates.
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An immunodominant epitope of the human immunodeficiency virus envelope glycoprotein gp160 recognized by class I major histocompatibility complex molecule-restricted murine cytotoxic T lymphocytes.
TLDR
The facts that CTL responses were detected in the context of only one of four class I MHC molecules tested and that the response was limited predominantly to a single epitope indicate that the CTL repertoire elicited by the HIV envelope protein in association with murine class IMHC molecules may be very limited.
View on PubMed
A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform.
TLDR
It is argued from the findings that the major conformational change underlying PrPSc formation occurs within the N-terminal segment of PrP 27-30.
View on PubMed
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.
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