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The structure of an antigenic determinant in a protein
The immunogenic and antigenic determinants of a synthetic peptide and the corresponding antigenic determinants in the parent protein have been elucidated. Four determinants have been defined byExpand
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General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.
  • R. Houghten
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 August 1985
A novel yet simple method is described that facilitates the synthesis of large numbers of peptides to the extent that the synthesis process need no longer be the limiting factor in many studiesExpand
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Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.
Apoptosis resistance commonly occurs in cancers, preventing activation of Caspase family cell death proteases. XIAP is an endogenous inhibitor of Caspases overexpressed in many cancers. We developedExpand
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Mapping the Prion Protein Using Recombinant Antibodies
ABSTRACT The fundamental event in prion disease is thought to be the posttranslational conversion of the cellular prion protein (PrPC) into a pathogenic isoform (PrPSc). The occurrence of PrPC on theExpand
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Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence
Chemically synthesized peptides corresponding to two different regions of the VP1 polypeptide of foot-and-mouth disease virus (FMDV) produced high levels of serotype-specific virus neutralizingExpand
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A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform.
The scrapie prion protein (PrPSc) is formed from the cellular isoform (PrPC) by a post-translational process that involves a profound conformational change. Linear epitopes for recombinant antibodyExpand
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Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.
Fifteen hexapeptides having high affinity for the opioid-like receptor ORL1 were identified from a combinatorial library containing more than 52 million different hexapeptides. The five compoundsExpand
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Induction of broadly cross-reactive cytotoxic T cells recognizing an HIV-1 envelope determinant.
An immunodominant determinant for cytotoxic T lymphocytes (CTLs) exists in the hypervariable portion of human immunodeficiency virus-1 (HIV-1) gp160. Three mouse CTL lines (specific for isolates MN,Expand
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Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: immunodominant T-cell domains map to the polymorphic regions of the molecule.
  • M. Good, D. Pombo, +6 authors L. Miller
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 1 February 1988
The definition of human T-cell antigenic sites is important for subunit vaccine development of a peptide immunogen if the goal is to allow antibody boosting during infection or to stimulateExpand
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Polyarginines Are Potent Furin Inhibitors*
The ubiquitous serine endoprotease furin has been implicated in the activation of bacterial toxins and viral glycoproteins as well as in the metastatic progression of certain tumors. Although highExpand
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