Tryptophan Metabolism Pathway

Known as: Tryptophan Metabolism, tryptophan metabolic process 
The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. [ISBN:0198547684]
National Institutes of Health

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22 relations
ALDH1B1 wt AlleleALDH2 wt AlleleAldehyde Dehydrogenase X, MitochondrialAldehyde Dehydrogenase, Mitochondrial, human
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Papers overview

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Review
2015
Review
2015
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
The brain-gut axis is a bidirectional communication system between the central nervous system and the gastrointestinal tract… (More)
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Highly Cited
2009
Highly Cited
2009
Quantitative profiling of biomarkers related to B-vitamin status, tryptophan metabolism and inflammation in human plasma by liquid chromatography/tandem mass spectrometry.
Vitamins B2 and B6 serve as cofactors in enzymatic reactions involved in tryptophan and homocysteine metabolism. Plasma… (More)
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Highly Cited
2008
Highly Cited
2008
Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
Half a century ago, chronic granulomatous disease (CGD) was first described as a disease fatally affecting the ability of… (More)
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Review
2006
Review
2006
Monitoring tryptophan metabolism in chronic immune activation.
The essential amino acid tryptophan is a constituent of proteins and is also a substrate for two important biosynthetic pathways… (More)
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Highly Cited
2005
Highly Cited
2005
Tryptophan metabolism and oxidative stress in patients with Huntington's disease.
Abnormalities in the kynurenine pathway may play a role in Huntington's disease (HD). In this study, tryptophan depletion and… (More)
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Highly Cited
2003
Highly Cited
2003
Interferon-alpha–induced changes in tryptophan metabolism: relationship to depression and paroxetine treatment
BACKGROUND Tryptophan (TRP) degradation into kynurenine (KYN) by the enzyme, indoleamine-2,3-dioxygenase, during immune… (More)
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Highly Cited
2002
Highly Cited
2002
T cell apoptosis by tryptophan catabolism
Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme that, expressed by different cell types, has regulatory… (More)
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Highly Cited
2000
Highly Cited
2000
DNA microarray analysis of gene expression in response to physiological and genetic changes that affect tryptophan metabolism in Escherichia coli.
We investigated the global changes in mRNA abundance in Escherichia coli elicited by various perturbations of tryptophan… (More)
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Review
1999
Review
1999
Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites.
The synthesis of NAD (or NADP) from tryptophan involves a series of enzymes and the formation of a number of intermediates which… (More)
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Highly Cited
1998
Highly Cited
1998
Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria.
The pathogenesis of human cerebral malaria (CM) remains unresolved. In the most widely used murine model of CM, the presence of T… (More)
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