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Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children.
Summary Aspects of 5-hydroxyindole metabolism have been studied in some groups of mentally retarded children. Six of 23 children with the diagnosis of infantile autism had consistently elevated bloodExpand
Lysergic acid diethylamide (LSD) administration selectively downregulates serotonin2 receptors in rat brain.
A dosage regimen of lysergic acid diethylamide (LSD) that reliably produces behavioral tolerance in rats was evaluated for effects on neurotransmitter receptor binding in rat brain using a variety ofExpand
Hyperserotonemia and amine metabolites in autistic and retarded children.
Mean whole blood serotonin (5-HT) levels were elevated in groups of autistic and severely retarded children. Eight of 27 (30%) individual autistic children, 13 of 25 (52%) severely retarded children,Expand
Serotonin2 agonist administration down-regulates rat brain serotonin2 receptors.
Daily administration of D-lysergic acid diethylamide (LSD) was previously shown to decrease serotonin2 (5-HT2) receptor binding in rat brain. Recently, 4-substituted derivatives ofExpand
Heroin epidemics.
Cardiovascular and subjective effects of intravenous cocaine administration in humans.
Nine volunteer subjects were tested with intravenously administered cocaine hydrochloride in doses ranging from 4 to 32 mg, as well as 10 mg of dextroamphetamine sulfate. Measures of cardiovascularExpand
"Psychedelic" experiences in acute psychoses.
The disease which thus evokes these new and wonderful talents and operations of the mind may be compared to an earthquake which, by convulsing the upper strata of our globe, throws upon its surfaceExpand
The effect of ethyl alcohol on man's electroencephalographic sleep cycle.
Abstract This study indicates that 1 g of ethyl alcohol per kg of body weight administered before sleep exerts a systematic effect on EEG sleep patterns. In three human subjects over 13 consecutiveExpand
Whole blood serotonin in autistic and normal subjects.
Whole blood serotonin and tryptophan were measured in 87 normal subjects and in 40 autistic subjects. Whole blood serotonin concentrations (mean +/- SE) were significantly higher in drug-free (N =Expand