Trypsinogen

Known as: Trypsinogen [Chemical/Ingredient] 
The inactive proenzyme of trypsin secreted by the pancreas, activated in the duodenum via cleavage by enteropeptidase. (Stedman, 25th ed)
National Institutes of Health

Related topics

Related topics

12 relations

Broader (1)

Enzyme Precursors
In BloodProcess of secretionTrypsinogen:MCnc:Pt:Ser/Plas:QnTrypsinogen:PrThr:Pt:Ser/Plas:Ord
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Narrower (1)

PRSS2 protein, human

Papers overview

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Review
2017
Review
2017
Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway
Genetic investigations have provided unique insight into the mechanism of chronic pancreatitis in humans and firmly established… (More)
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Highly Cited
2009
Highly Cited
2009
Golden Gate Shuffling: A One-Pot DNA Shuffling Method Based on Type IIs Restriction Enzymes
We have developed a protocol to assemble in one step and one tube at least nine separate DNA fragments together into an acceptor… (More)
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Highly Cited
2006
Highly Cited
2006
Hereditary pancreatitis caused by triplication of the trypsinogen locus
Hereditary pancreatitis has been reported to be caused by 'gain-of-function' missense mutations in the cationic trypsinogen gene… (More)
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Highly Cited
2000
Highly Cited
2000
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis.
Autodigestion of the pancreas by its own prematurely activated digestive proteases is thought to be an important event in the… (More)
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Highly Cited
1999
Highly Cited
1999
A signal peptide cleavage site mutation in the cationic trypsinogen gene is strongly associated with chronic pancreatitis.
BACKGROUND & AIMS In pancreatitis, a key role has been attributed to the inappropriate conversion of trypsinogen to trypsin… (More)
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Highly Cited
1998
Highly Cited
1998
Intra-acinar cell activation of trypsinogen during caerulein-induced pancreatitis in rats.
Supramaximal stimulation of the pancreas with the CCK analog caerulein causes acute edematous pancreatitis. In this model, active… (More)
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Highly Cited
1997
Highly Cited
1997
Evolution of antifreeze glycoprotein gene from a trypsinogen gene in Antarctic notothenioid fish.
Freezing avoidance conferred by different types of antifreeze proteins in various polar and subpolar fishes represents a… (More)
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Highly Cited
1997
Highly Cited
1997
Mutations in the cationic trypsinogen gene are associated with recurrent acute and chronic pancreatitis.
BACKGROUND & AIMS We recently identified a single R117H mutation in the cationic trypsinogen gene in several kindreds with an… (More)
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Highly Cited
1997
Highly Cited
1997
Cerulein-induced in vitro activation of trypsinogen in rat pancreatic acini is mediated by cathepsin B.
BACKGROUND & AIMS One of the central, unresolved issues in the pathogenesis of acute pancreatitis is the uncertainty regarding… (More)
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Highly Cited
1996
Highly Cited
1996
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene
Hereditary pancreatitis (HP) is a rare, early-onset genetic disorder characterized by epigastric pain and often more serious… (More)
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