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Trimedoxime

Known as: Trimedoxime [Chemical/Ingredient], TMB-4, Pyridinium, 1,1'-(1,3-propanediyl)bis(4-(hydroxyimino)methyl)-, dibromide 
Cholinesterase reactivator used as an antidote in alkyl phosphate poisoning.
National Institutes of Health

Related topics

Related topics

11 relations

Broader (2)

AntidoteCholinesterase Reactivators
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (2)

Trimedoxime BromideUNO 3

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
In vivo reactivation by oximes of inhibited blood, brain and peripheral tissue cholinesterase activity following exposure to nerve agents in guinea pigs.
2008
2008
Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro.
Highly Cited
2007
Highly Cited
2007
Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates.
2007
2007
A comparison of trimedoxime, obidoxime, pralidoxime and HI-6 in the treatment of oral organophosphorus insecticide poisoning in the rat
This study summarizes the results of examination of acute oral toxicity of 26 organophosphorus insecticides in rats. The… 
Highly Cited
1996
Highly Cited
1996
Oxime-induced reactivation of acetylcholinesterase inhibited by phosphoramidates.
Highly Cited
1992
Highly Cited
1992
Feeding behavior and brain acetylcholinesterase activity in bream (Abramis brama L.) as affected by DDVP, an organophosphorus insecticide.
Highly Cited
1983
Highly Cited
1983
The efficacy of bispyridinium derivatives in the treatment of organophosphonate poisoning in the guinea‐pig
The efficacy of a number of bispyridinium compounds, including both oxime and non‐oxime derivatives, has been determined against… 
1970
1970
The binding of sarin in the blood plasma of the rat.
1965
1965
Action of fluoride on cholinesterase. II. In vitro reactivation of cholinesterases inhibited by organophosphorous compounds.
Highly Cited
1963
Highly Cited
1963
ANTIDOTAL ACTION OF PYRIDINIUM OXIMES IN ANTICHOLINESTERASE POISONING; COMPARATIVE EFFECTS OF SOMAN, SARIN, AND NEOSTIGMINE ON NEUROMUSCULAR FUNCTION.
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