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Trimedoxime

Known as: Trimedoxime [Chemical/Ingredient], TMB-4, Pyridinium, 1,1'-(1,3-propanediyl)bis(4-(hydroxyimino)methyl)-, dibromide 
Cholinesterase reactivator used as an antidote in alkyl phosphate poisoning.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Poisoning by organophosphorus compounds (OP) still is a major therapeutic problem. Intentional OP pesticide poisoning results in… Expand
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Review
2013
Review
2013
Recent news from Syria on a possible use of chemical warfare agents made the headlines. Furthermore, the motivation of terrorists… Expand
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Highly Cited
2011
Highly Cited
2011
Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE… Expand
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Highly Cited
2009
Highly Cited
2009
Evaluation of Oxime K203 as Antidote in Tabun Poisoning We studied bispyridinium oxime K203 [(E)-1-(4-carbamoylpyridinium)-4-(4… Expand
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Highly Cited
2006
Highly Cited
2006
The increased concern about terrorist use of nerve agents prompted us to search for new more effective oximes against tabun and… Expand
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Highly Cited
1996
Highly Cited
1996
The reaction of human erythrocyte acetylcholinesterase (AChE) with a set of structurally related phosphoramidates was studied in… Expand
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Highly Cited
1992
Highly Cited
1992
1. Bream (Abramis brama) were exposed to sublethal concentration of organophosphorus insecticide DDVP and the amount of food… Expand
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Highly Cited
1983
Highly Cited
1983
The efficacy of a number of bispyridinium compounds, including both oxime and non‐oxime derivatives, has been determined against… Expand
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Highly Cited
1965
Highly Cited
1965
The oximes P2S, TMB-4 and Toxogonin have been tested as reactivators of Sarin and Tabun inhibited acetylcholinesterase. The… Expand
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Highly Cited
1963
Highly Cited
1963
Abstract Treatment of poisoning from organophosphate anticholinesterase agents with atropine plus an oxime is highly effective… Expand
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