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Trimedoxime

Known as: Trimedoxime [Chemical/Ingredient], TMB-4, Pyridinium, 1,1'-(1,3-propanediyl)bis(4-(hydroxyimino)methyl)-, dibromide 
Cholinesterase reactivator used as an antidote in alkyl phosphate poisoning.
National Institutes of Health

Related topics

Related topics

11 relations

Broader (2)

AntidoteCholinesterase Reactivators
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (2)

Trimedoxime BromideUNO 3

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
A comparison of trimedoxime, obidoxime, pralidoxime and HI-6 in the treatment of oral organophosphorus insecticide poisoning in the rat
This study summarizes the results of examination of acute oral toxicity of 26 organophosphorus insecticides in rats. The… 
1995
1995
Oxime effects on the rate constants of carbamylation and decarbamylation of acetylcholinesterase for pyridostigmine, physostigmine and insecticidal carbamates
1992
1992
Studies of the amplification of carbaryl toxicity by various oximes.
1983
1983
Efficacy of mono- and bis-pyridinium oximes versus soman, sarin and tabun poisoning in mice.
Various oximes (PAM, toxogonin, TMB-4, HS-6, HI-6, HGG-12, HGG-42) combined with atropine were compared as antidotes of soman… 
1979
1979
The effects of atropine-oxime therapy on cholinesterase activity and survival of animals intoxicated with p-nitrophenyl di-n-butylphosphinate.
1972
1972
Structure-activity relationship of mono- and bisquaternary pyridines in regard to their parasympatholytic effects.
1970
1970
The binding of sarin in the blood plasma of the rat.
1965
1965
Action of fluoride on cholinesterase. II. In vitro reactivation of cholinesterases inhibited by organophosphorous compounds.
Highly Cited
1963
Highly Cited
1963
ANTIDOTAL ACTION OF PYRIDINIUM OXIMES IN ANTICHOLINESTERASE POISONING; COMPARATIVE EFFECTS OF SOMAN, SARIN, AND NEOSTIGMINE ON NEUROMUSCULAR FUNCTION.
1958
1958
Chemotherapeutic Effectiveness of 1,1'-Trimethylene Bis (4-Formylpyridinium Bromide) Dioxime (TMB-4) in Experimental Anticholinesterase Poisoning
Treatment of serious poisoning by phosphate and phosphonate esters of the “nerve gas” and insecticide type relies principally on… 
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