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Cholinesterase Reactivators

Known as: Reactivators, Cholinesterase 
Drugs used to reverse the inactivation of cholinesterase caused by organophosphates or sulfonates. They are an important component of therapy in… 
National Institutes of Health

Related topics

Related topics

22 relations
AntidoteButyrylcholinesteraseCholinesterase Reactivator [EPC]Cholinesterases

Broader (2)

Enzyme ReactivatorsParasympatholytics

Narrower (10)

HLo 7Insecticides, Organothiophosphate, AntagonistsObidoxime ChlorideOrganophosphate Insecticide Antagonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Acetylcholinesterase Reactivators (HI-6, Obidoxime, Trimedoxime, K027, K075, K127, K203, K282): Structural Evaluation of Human Serum Albumin Binding and Absorption Kinetics
Acetylcholinesterase (AChE) reactivators (oximes) are compounds predominantly targeting the active site of the enzyme. Toxic… 
2008
2008
The effect of HI-6 on cholinesterases and on the cholinergic system of the rat bladder.
2007
2007
Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents.
Understanding the mechanism of action of organophosphates (OP)/nerve agents -- irreversible acetylcholinesterase (AChE, EC 3.1.1… 
2005
2005
A new group of monoquaternary reactivators of acetylcholinesterase inhibited by nerve agents
Reactivators of acetylcholinesterase (AChE; EC 3.1.1.7) are able to treat intoxication by organophosphorus compounds, especially… 
1991
1991
Actions and interactions of cholinolytics and cholinesterase reactivators in the treatment of acute organophosphorus toxicity.
Different drug combinations consisting of cholinolytic and a cholinesterase (ChE) reactivator provide greater therapeutic… 
1986
1986
Nonquaternary cholinesterase reactivators. 4. Dialkylaminoalkyl thioesters of alpha-keto thiohydroximic acids as reactivators of ethyl methylphosphonyl- and 1,2,2-trimethylpropyl methylphosphonyl…
In the search for improved lipophilic centrally active acetylcholinesterase (AChE) antidotes, a series of alpha-keto… 
1985
1985
Clinical observation and comparison of the effectiveness of several oxime cholinesterase reactivators.
After passing toxicity and experimental therapeutic tests, four oxime cholinesterase reactivators [PAM (pyridine aldoxime… 
1982
1982
Nonquaternary Cholinesterase Reactivators.
Abstract : We prepared a series of dialkylaminoalkyl alpha-ketothiohydroximates and evaluated them in vitro as reactivators of… 
1981
1981
Nonquaternary cholinesterase reactivators. Dialkylaminoalkyl thioesters of alpha-ketothiohydroximic acids as reactivators of diisopropyl phosphorofluoridate inhibited acetylcholinesterase.
We have prepared a series of alpha-ketothiohydroximic acid thioesters and evaluated them in vitro with respect to their ability… 
1977
1977
Cholinomimetic teratogens. V. The effect of oximes and related cholinesterase reactivators.
Pyridine-2-aldoxime methiodide and pyridine-2-aldoxime methyl methane sulfonate (P2S) used as supplements to carbachol or… 
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