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Condensed and hydrolysable tannins as antioxidants influencing the health.
TLDR
This review offers a general description of chemistry of both hydrolysable and condensed tannins (proanthocyanidins), the mechanisms of their antioxidation action, like free radical scavenging activity, chelation of transition metals, inhibition of prooxidative enzymes and lipid peroxidation. Expand
Chemical aspects of pharmacological prophylaxis against nerve agent poisoning.
TLDR
Future development will be focused on scavengers acting before the binding of nerve agent to the target sites, and on other drugs reversible cholinesterase inhibitors (e.g. huperzine A, physostigmine, acridine derivatives etc.). Expand
Treatment of organophosphate intoxication using cholinesterase reactivators: facts and fiction.
TLDR
Reactivation of cholinesterases in the peripheral and central nervous system is described and it is underlined its importance for the survival or death of the organism poisoned with OP. Expand
In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity.
TLDR
The potency of the oximes K048 and K027 to protect mice from five-fold LD50 oftabun and their low toxicity make these compounds leading in the therapy of tabun poisoning. Expand
Phosphatidylinositol 3-Kinase (PI3K) and phosphatidylinositol 3-kinase-related kinase (PIKK) inhibitors: importance of the morpholine ring.
TLDR
While several PI3K pathway inhibitors have recently shown promising clinical responses, inhibitors of the DNA damage-related PIKKs remain thus far largely in preclinical development. Expand
Monooxime reactivators of acetylcholinesterase with (E)-but-2-ene linker: preparation and reactivation of tabun- and paraoxon-inhibited acetylcholinesterase.
TLDR
Fifteen new monooxime reactivators of acetylcholinesterase with a (E-but-2-ene linker were developed in an effort to extend the properties of K-oxime (E)-1-(4-carbamoylpyridinium)-4-hydroxyiminomethylpyrid inium)-but- 2-ene dibromide (K203). Expand
Pretreatment with pyridinium oximes improves antidotal therapy against tabun poisoning.
TLDR
BChE could scavenge tabun prior to AChE inhibition, but fast oxime-assisted reactivation of tabun-inhibited AchE or protection of ACh E by oxime against inhibition with tabun would not be obstructed by interaction between BChE and oximes. Expand
Russian VX: inhibition and reactivation of acetylcholinesterase compared with VX agent.
TLDR
Compared differences in the in vitro inhibition potency of VX and Russian VX on rat, pig and human brain, and tested reactivation of rat brain cholinesterase inhibited by these agents using oxime HI-6, obidoxime, pralidoximes, trimedoxime and methoxime confirm that HI- 6 is currently the most potent reactivator of AChE inhibited by nerve agents. Expand
Synthesis of monooxime-monocarbamoyl bispyridinium compounds bearing (E)-but-2-ene linker and evaluation of their reactivation activity against tabun- and paraoxon-inhibited acetylcholinesterase.
TLDR
Six AChE monooxime-monocarbamoyl reactivators with an (E)-but-2-ene linker were synthesized using modification of currently known synthetic pathways and according to the results obtained, one reactivator seems to be promising against tabun-inhibited A ChE and two reactvators against paraoxon-in inhibited ACh E. Expand
Acetylcholinesterases – the structural similarities and differences
TLDR
The various primary and tertiary alignments show that AChEs are very evolutionary conserved enzymes and this fact could lead to difficulties, for example, in the search for inhibitors specific for a particular species. Expand
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