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Trientine hydrochloride

Known as: N,N-bis (2-aminoethyl)-1,2-ethanediamine Dihydrochloride, Trientine Dihydrochloride, trientine hcl 
The hydrochloride salt form of a metal chelating agent with potential anti-angiogenic activity. Trientine chelates excess copper (Cu) ions in the… 
National Institutes of Health

Related topics

Related topics

9 relations
Biliary cirrhosisChelating Activity [MoA]CystinuriaDrug Allergy

Narrower (1)

Syprine

Broader (1)

Trientine

Papers overview

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2018
2018
Addressing Generic-Drug Market Failures - The Case for Establishing a Nonprofit Manufacturer.
Addressing Generic-Drug Market Failures One market-based solution to stimulating competition in generic-drug markets is to… 
2005
2005
Wilson’s disease with depression and parkinsonism
2005
2005
Combination of copper-chelating agent, trientine, and methotrexate attenuates colorectal carcinoma development and angiogenesis in mice.
Recent studies have suggested that an anti-angiogenic agent could improve the inhibitory effects of standard chemotherapeutic… 
2003
2003
The copper-chelating agent, trientine, attenuates liver enzyme-altered preneoplastic lesions in rats by angiogenesis suppression.
It has been shown that angiogenesis plays an important role not only in tumor growth, but also in carcinogenesis. We previously… 
Highly Cited
2001
Highly Cited
2001
The copper‐chelating agent, trientine, suppresses tumor development and angiogenesis in the murine hepatocellular carcinoma cells
Angiogenesis is now recognized as a crucial process in tumor development, including hepatocellular carcinoma (HCC). Since HCC is… 
1997
1997
The Mechanism of Excretion of Trientine from the Rat Kidney: Trientine is not Recognized by the H+/Organic Cation Transporter
Trientine dihydrochloride is used to treat Wilson's disease by chelating copper and increasing its urinary excretion. The… 
Highly Cited
1996
Highly Cited
1996
Inhibition of hereditary hepatitis and liver tumor development in Long‐Evans cinnamon rats by the copper‐chelating agent trientine dihydrochloride
Trientine dihydrochloride (trientine) is an alternative medicinal copper chelating agent for patients with Wilson's disease of… 
1994
1994
Superficial hemosiderosis of the central nervous system
Superficial hemosiderosis (SH) of the CNS is a rare disease caused by repeated subarachnoid hemorrhage, with progressive… 
1994
1994
Measurement of blood holoceruloplasmin by EIA using a mouse monoclonal antibody directed to holoceruloplasmin. Implication for mass screening of Wilson disease
Wilson disease (McKusick 277900) is an autosomal recessive disorder in which the biliary excretion of copper and its… 
1987
1987
A normal-phase high-performance liquid chromatographic assay for aziridine residue in trientine dihydrochloride.
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