The copper‐chelating agent, trientine, suppresses tumor development and angiogenesis in the murine hepatocellular carcinoma cells

@article{Yoshii2001TheCA,
  title={The copper‐chelating agent, trientine, suppresses tumor development and angiogenesis in the murine hepatocellular carcinoma cells},
  author={J. Yoshii and H. Yoshiji and S. Kuriyama and Y. Ikenaka and R. Noguchi and H. Okuda and H. Tsujinoue and T. Nakatani and H. Kishida and D. Nakae and D. Gomez and M. D. De Lorenzo and A. Tejera and H. Fukui},
  journal={International Journal of Cancer},
  year={2001},
  volume={94}
}
Angiogenesis is now recognized as a crucial process in tumor development, including hepatocellular carcinoma (HCC). Since HCC is known as a hypervascular tumor, anti‐angiogenesis is a promising approach to inhibit the HCC development. Trientine dihydrochloride (trientine) is used in clinical practice as an alternative copper (Cu)‐chelating agent for patients with Wilson's disease of penicillamine intolerance. In our study, we examined the effect of Cu‐chelating agents on tumor development and… Expand
The copper chelator trientine has an antiangiogenic effect against hepatocellular carcinoma, possibly through inhibition of interleukin‐8 production
TLDR
The chelating effect of trientine prevented copper from functioning as a cofactor in angiogenesis, which resulted in reduced IL‐8 production from HuH‐7 cells. Expand
Trientine, a copper-chelating agent, induced apoptosis in murine fibrosarcoma cells in vivo and in vitro.
TLDR
Results show that apoptosis was induced in tumor cells by treatment with trientine in vivo and in vitro, and this agent is widely accepted as being required for angiogenesis. Expand
Trientine, a copper-chelating agent, induced apoptosis in murine fibrosarcoma cells by activation of the p38 MAPK pathway.
TLDR
The present results showed that the p38 MAPK pathway may play an important role in induction of apoptosis in fibrosarcoma cells by trientine. Expand
Antitumour Effect of a Mixture of N-Propyl Polysulfides In Vitro
TLDR
The results of the MTT assays indicate that this standardized mixture of n-propyl polysulfides has a strong, dose-dependent cytotoxic effect against all three of the tested tumour cell lines (CT26, 4T1, B16F10). Expand
Evaluation of chelating agents as anti-angiogenic therapy through copper chelation.
The evaluation of several sets of polyamine donor chelating agents including a selection of novel hexadentate 1,3,5-cis,cis-triaminocyclohexane (tach) based derivatives were performed in an in vitroExpand
Combined effects of treatment with trientine, a copper-chelating agent, and x-irradiation on tumor growth in transplantation model of a murine fibrosarcoma.
TLDR
It was shown that trientine and X-irradiation interacted additively in inhibition of tumor growth and the surviving fractions of the pretreated cells were lower than those of cells without treatment. Expand
Chelators at the Cancer Coalface: Desferrioxamine to Triapine and Beyond
TLDR
Chelators originally designed to treat disorders of copper overload, such as penicillamine, trientine, and tetrathiomolybdate, have also emerged as potential anticancer drugs, as they are able to target the key angiogenic cofactor, copper. Expand
Rapid Copper Acquisition by Developing Murine Mesothelioma: Decreasing Bioavailable Copper Slows Tumor Growth, Normalizes Vessels and Promotes T Cell Infiltration
TLDR
Lowing bioavailable copper using the copper chelators, penicillamine, trientine or tetrathiomolybdate slowed in vivo mesothelioma growth but did not provide any cures similar to using cisplatin chemotherapy or anti-VEGF receptor antibody therapy. Expand
The role of copper in drug-resistant murine and human tumors
TLDR
It was found that the blood serum of tumor-bearing mice contained higher amounts of copper than healthy mice with tumors, and the copper levels in serum of healthy volunteers were lower than in cancer patients irrespective of their response to chemotherapy. Expand
Clioquinol and pyrrolidine dithiocarbamate complex with copper to form proteasome inhibitors and apoptosis inducers in human breast cancer cells
TLDR
The feature of breast cancer cells and tissues to accumulate copper can be used as a targeting method for anticancer therapy through treatment with novel compounds such as CQ and PDTC that become active proteasome inhibitors and breast cancer cell killers in the presence of copper. Expand
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