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Transcription Factor AP-1, human

Known as: AP1, JUN, v-jun Avian Sarcoma Virus 17 Oncogene Homolog 
Transcription factor AP-1 (331 aa, ~36 kDa) is encoded by the human JUN gene. This protein plays a role in transcriptional activation.
National Institutes of Health

Related topics

Related topics

48 relations
AP1 complexAP1 complex locationATM Signaling PathwayAgrin Pathway

Broader (1)

Transcription Factor AP-1

Papers overview

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2019
2019
Hydrangea serrata (Thunb.) Ser. Extract Attenuate UVB-Induced Photoaging through MAPK/AP-1 Inactivation in Human Skin Fibroblasts and Hairless Mice
Skin photoaging is mainly caused by exposure to ultraviolet (UV) light, which increases expressions of matrix metalloproteinases… 
2010
2010
Membrane association facilitates degradation and cleavage of the cyclin-dependent kinase 5 activators p35 and p39.
Cyclin-dependent kinase 5 (Cdk5) is activated by binding to its activators, p35 and p39. The level of Cdk5 activity is determined… 
Highly Cited
2002
Highly Cited
2002
Calpain-mediated Cleavage of the Cyclin-dependent Kinase-5 Activator p39 to p29*
The activity of cyclin-dependent kinase-5 (Cdk5) is tightly regulated by binding of its neuronal activators p35 and p39. Upon… 
Highly Cited
2001
Highly Cited
2001
Resveratrol inhibits phorbol ester and UV-induced activator protein 1 activation by interfering with mitogen-activated protein kinase pathways.
Resveratrol, a phenolic compound found in grapes and other food products, prevents chemical-induced carcinogenesis in a number of… 
Highly Cited
2000
Highly Cited
2000
Activation of c-Jun N-terminal kinase and activator protein 1 by receptor activator of nuclear factor kappaB.
Receptor activator of nuclear factor kappaB (RANK), a lately identified member of the tumor necrosis factor receptor superfamily… 
Highly Cited
1999
Highly Cited
1999
Cell-Extracellular Matrix Interactions Stimulate the AP-1 Transcription Factor in an Integrin-Linked Kinase- and Glycogen Synthase Kinase 3-Dependent Manner
ABSTRACT Integrin-mediated interactions of cells with components of the extracellular matrix regulate cell survival, cell… 
Highly Cited
1996
Highly Cited
1996
Specific Interaction of Glyceraldehyde 3-Phosphate Dehydrogenase with the 5′-Nontranslated RNA of Hepatitis A Virus*
Initiation of translation of hepatitis A virus (HAV) RNA occurs by internal entry and is likely to involve the interaction of… 
Highly Cited
1994
Highly Cited
1994
c-Jun represses transcription of the human chorionic gonadotropin alpha and beta genes through distinct types of CREs.
Highly Cited
1992
Highly Cited
1992
Embryonic stem (ES) cells lacking functional c-jun: consequences for growth and differentiation, AP-1 activity and tumorigenicity.
The proto-oncogene c-jun encodes the major component of the transcription factor AP-1 and is thought to have important functions… 
Highly Cited
1988
Highly Cited
1988
Epidermal growth factor stimulates transcription of the c-jun proto-oncogene in rat fibroblasts
Some growth factor-induced genes, such as the c-fos gene, are activated rapidly and transiently without intervening protein… 
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