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Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
It is reported that ceramide initiates apoptosis through the SAPK cascade and evidence is provided for a signalling mechanism that integrates cytokine- and stress-activated apoptosis. Expand
p53: a frequent target for genetic abnormalities in lung cancer.
These findings, coupled with the previous demonstration of 17p allele loss in lung cancer, strongly implicate p53 as an anti-oncogene whose disruption is involved in the pathogenesis of human lung cancer. Expand
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73
Site-directed mutagenesis indicates that phosphorylation of these serines is essential for stimulation of c-Jun activity and for cooperation with Ha-ras in ocogenic transformation. Expand
A Glycine-Dependent Riboswitch That Uses Cooperative Binding to Control Gene Expression
Expression profiling of serous low malignant potential, low-grade, and high-grade tumors of the ovary.
The expression profiles of LMP, low-grade, and high- grade papillary serous ovarian carcinomas suggest that LMP tumors are distinct from high-grade cancers; however, they are remarkably similar to low- grade cancers. Expand
Ras Uses the Novel Tumor Suppressor RASSF1 as an Effector to Mediate Apoptosis*
- M. Vos, C. Ellis, A. Bell, M. Birrer, G. Clark
- Biology, Medicine
- The Journal of Biological Chemistry
- 17 November 2000
It is shown that RASSF1 binds Ras in a GTP-dependent manner, both in vivo and directlyin vitro, and may serve as a novel Ras effector that mediates the apoptotic effects of oncogenic Ras. Expand
RASSF6 is a novel member of the RASSF family of tumor suppressors
RASSF6 is a novel RASSF family member that demonstrates the properties of a Ras effector and tumor suppressor but exhibits biological properties that are unique and distinct from those of other family members. Expand
The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers.
- E. Zudaire, N. Cuesta, +10 authors F. Cuttitta
- Medicine, Biology
- The Journal of clinical investigation
- 1 February 2008
It is demonstrated that AHRR is a putative new tumor suppressor gene in multiple types of human cancers and DNA hypermethylation as the regulatory mechanism of A HRR gene silencing is demonstrated. Expand
NORE1A tumor suppressor candidate modulates p21CIP1 via p53.
The molecular basis of Nore1A-mediated growth inhibition is defined and NORE1A is implicate as a potential component of the ill-defined connection between Ras and p53. Expand
Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells.
- Z. Dong, M. Birrer, R. Watts, L. Matrisian, N. Colburn
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 18 January 1994
Results indicate that AP-1 activity is required for TPA- or EGF-induced transformation in JB6 P+ cells, and demonstrates that a specific block in induced AP- 1 activity inhibits tumor promoter- induced transformation. Expand