Transcription Elongation

The RNA polymerase moves along the DNA template, adding nucleotides to the growing RNA chain in accordance with the sequence of the template or… (More)
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
During transcription of protein-coding genes, bacterial RNA polymerase (RNAP) is closely followed by a ribosome that translates… (More)
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Highly Cited
2007
Highly Cited
2007
The RNA polymerase elongation complex (EC) is both highly stable and processive, rapidly extending RNA chains for thousands of… (More)
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Review
2006
Review
2006
Hundreds of protein factors participate in transcription and its regulation in eukaryotes. Many of these proteins regulate… (More)
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Highly Cited
2005
Highly Cited
2005
Yeast Rpd3 histone deacetylase plays an important role at actively transcribed genes. We characterized two distinct Rpd3… (More)
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Highly Cited
2003
Highly Cited
2003
Genetic instability, a phenomenon relevant for developmentally regulated processes, cancer, and inherited disorders, can be… (More)
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Highly Cited
2003
Highly Cited
2003
Previous studies have suggested that transcription elongation results in changes in chromatin structure. Here we present studies… (More)
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Highly Cited
2000
Highly Cited
2000
The path of the nucleic acids through a transcription elongation complex was tracked by mapping cross-links between bacterial RNA… (More)
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Highly Cited
1998
Highly Cited
1998
We report the identification of a transcription elongation factor from HeLa cell nuclear extracts that causes pausing of RNA… (More)
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Highly Cited
1997
Highly Cited
1997
P-TEFb is a key regulator of the process controlling the processivity of RNA polymerase II and possesses a kinase activity that… (More)
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Highly Cited
1995
Highly Cited
1995
Germline mutations in the von Hippel-Lindau tumor suppressor gene (VHL) predispose individuals to a variety of tumors, including… (More)
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