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Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay.
It is shown that alternative skipping of PTB exon 11 leads to an mRNA that is removed by NMD and that this pathway consumes at least 20% of the PTB mRNA in HeLa cells, indicating a high prevalence of human alternative splicing leading to NMD. Expand
Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis
Allelic association of a polymorphism in the gene encoding the interleukin 7 receptor α chain ( IL7R) is described as a significant risk factor for multiple sclerosis in four independent family-based or case-control data sets. Expand
Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors
A human protein essential for splicing in vitro, called alternative splicing factor/splicing factor 2, is shown to cooperate with the U1 snRNP particle in binding pre-mRNA. Expand
Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo.
The results indicate that the RIP assay is a powerful tool to identify RNA-protein interactions in vivo and has the potential to unravel the cellular network of RNP complexes in their native setting. Expand
Zika virus: History, emergence, biology, and prospects for control.
Zika virus (ZIKV), a previously obscure flavivirus closely related to dengue, West Nile, Japanese encephalitis and yellow fever viruses, has emerged explosively since 2007 to cause a series ofExpand
N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection
It is demonstrated that m6A modulates infection by hepatitis C virus (HCV) and is identified as a conserved regulatory mark across Flaviviridae genomes. Expand
Discovery of Insect and Human Dengue Virus Host Factors
This work identifies insect host factors required for DENV-2 propagation, by carrying out a genome-wide RNA interference screen in Drosophila melanogaster cells using a well-established double-stranded RNA library, and suggests new approaches to control infection in the insect vector and the mammalian host. Expand
Polypyrimidine Tract Binding Protein Antagonizes Exon Definition
It is proposed here that PTB multimerization sequesters these exons to prevent exon definition, likely critical not only to prevent inclusion of pseudo-exons but also to set up cell-type-specific exondefinition. Expand
A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection.
A library of FDA-approved drugs was interrogated for their ability to block infection of human HuH-7 cells by a newly isolated ZIKV strain (ZIKV MEX_I_7) and established anti-flaviviral drugs and others that had no previously known antiviral activity were identified as inhibitors of ZikV infection. Expand
Circulating Tumor Cells from Patients with Advanced Prostate and Breast Cancer Display Both Epithelial and Mesenchymal Markers
The existence and high frequency of these C TCs coexpressing epithelial, mesenchymal, and stem cell markers in patients with progressive metastases has important implications for the application and interpretation of approved methods to detect CTCs. Expand