Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay.
- M. Wollerton, C. Gooding, E. Wagner, M. Garcia-Blanco, Christopher W. J. Smith
- BiologyMolecules and Cells
- 16 January 2004
Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis
- S. Gregory, S. Schmidt, M. Pericak-Vance
- BiologyNature Genetics
- 1 September 2007
Allelic association of a polymorphism in the gene encoding the interleukin 7 receptor α chain ( IL7R) is described as a significant risk factor for multiple sclerosis in four independent family-based or case-control data sets.
Zika virus: History, emergence, biology, and prospects for control.
- S. Weaver, F. Costa, N. Vasilakis
- Medicine, BiologyAntiviral Research
- 1 June 2016
Reversible cross-linking combined with immunoprecipitation to study RNA-protein interactions in vivo.
- S. Niranjanakumari, Erika L. Lasda, R. Brazas, M. Garcia-Blanco
- BiologyMethods
- 1 February 2002
N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection
- Nandan S. Gokhale, Alexa B. R. McIntyre, Stacy M. Horner
- BiologyCell Host and Microbe
- 9 November 2016
Protein–protein interactions and 5'-splice-site recognition in mammalian mRNA precursors
- J. Kohtz, S. Jamison, J. Manley
- BiologyNature
- 10 March 1994
A human protein essential for splicing in vitro, called alternative splicing factor/splicing factor 2, is shown to cooperate with the U1 snRNP particle in binding pre-mRNA.
A Screen of FDA-Approved Drugs for Inhibitors of Zika Virus Infection.
- Nicholas J. Barrows, R. K. Campos, M. Garcia-Blanco
- Biology, MedicineCell Host and Microbe
- 10 August 2016
Polypyrimidine Tract Binding Protein Antagonizes Exon Definition
- E. Wagner, M. Garcia-Blanco
- BiologyMolecular and Cellular Biology
- 15 May 2001
It is proposed here that PTB multimerization sequesters these exons to prevent exon definition, likely critical not only to prevent inclusion of pseudo-exons but also to set up cell-type-specific exondefinition.
Discovery of Insect and Human Dengue Virus Host Factors
- O. Sessions, Nicholas J. Barrows, M. Garcia-Blanco
- BiologyNature
- 23 April 2009
This work identifies insect host factors required for DENV-2 propagation, by carrying out a genome-wide RNA interference screen in Drosophila melanogaster cells using a well-established double-stranded RNA library, and suggests new approaches to control infection in the insect vector and the mammalian host.
Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness
- G. Manokaran, E. Finol, E. Ooi
- Biology, MedicineScience
- 9 October 2015
These findings demonstrate a distinctive viral RNA–host protein interaction to evade the innate immune response for increased epidemiological fitness.
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