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Trabedersen

A transforming growth factor (TGF)-beta2 specific phosphorothioate antisense oligodeoxynucleotide with the sequence 5'-CGGCATGTCTATTTTGTA-3', with… Expand
National Institutes of Health

Papers overview

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2017
2017
4034 Background: TGF-β2 overexpression in solid tumors triggers key cancer pathomechanisms, i.e. suppression of antitumor immune… Expand
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2014
2014
BACKGROUND LC-MS/MS allows quantification of therapeutic oligonucleotides in biological fluids at low ng/ml concentrations… Expand
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Highly Cited
2011
Highly Cited
2011
This randomized, open-label, active-controlled, dose-finding phase IIb study evaluated the efficacy and safety of trabedersen (AP… Expand
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Highly Cited
2011
Highly Cited
2011
Pancreatic cancer is one of the most aggressive human cancers with a 5-year survival rate of <5%. Overexpression of transforming… Expand
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Review
2011
Review
2011
Despite remarkable advances in cancer research, patients with malignant tumors such as high-grade glioma or advanced pancreatic… Expand
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Review
2011
Review
2011
Pancreatic cancer has high incidence and mortality rates, and effective treatment remains a clinical challenge. As deregulation… Expand
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2011
2011
2513 Background: TGF-β2 regulates key cancer mechanisms, particularly immunosuppression and metastasis. The antisense… Expand
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2009
2009
  • Luc Vallières
  • IDrugs : the investigational drugs journal
  • 2009
  • Corpus ID: 23058142
Trabedersen (AP-12009), which is being developed by Antisense Pharma GmbH, is a synthetic antisense oligodeoxynucleotide designed… Expand
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2009
2009
2037 Background: High-grade gliomas (HGG) strongly overexpress TGF-beta 2. Trabedersen (AP 12009), a TGF-beta 2-specific… Expand
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2009
2009
4619 Background: TGF-beta 2 is one of the most potent immunosuppressors and mediates escape from immunosurveillance. It also… Expand
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