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Platinum-induced neurotoxicity and preventive strategies: past, present, and future.
TLDR
Dose adjustment and/or drug withdrawal seem to be the most frequently used methods in the management of platinum-induced peripheral neurotoxicity, and studies on in vitro models and appropriate trials planning should be integrated into the future design of neuroprotective strategies to find the best patient-oriented solution. Expand
Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia
TLDR
Lactate dehydrogenase A is a viable target in PDAC, and novel LDH-A inhibitors display synergistic cytotoxic activity with gemcitabine, offering an innovative tool in hypoxic tumours. Expand
Therapeutic Potential of Targeting Wnt/β‐Catenin Pathway in Treatment of Colorectal Cancer: Rational and Progress
TLDR
This review summarizes the current knowledge about the therapeutic potential of targeting Wnt pathway with particular emphasis on preclinical/clinical studies in treatment of colorectal cancer. Expand
EGFR as a potential target for the treatment of pancreatic cancer: dilemma and controversies.
TLDR
The critical role of EGFR pathway in pancreatic-cancer, strategies to enhance the effectiveness of EG FRinhibitors as well as the preclinical/clinical studies with particular emphasis on recent findings with monoclonal antibodies and tyrosine-inhibitor studies are described. Expand
MicroRNAs as potential diagnostic and prognostic biomarkers in melanoma.
TLDR
Preclinical and clinical studies on circulating miRNAs and their potential role as diagnosis, and therapeutic targets in melanoma are highlighted, suggesting their modulation as a potential approach to overcome chemoresistance. Expand
The prognostic value of MGMT promoter methylation in glioblastoma: A meta‐analysis of clinical trials
TLDR
This data showed a significant association with better OS and PFS, although further studies are warranted to assess the value of emerging marker in prospective setting in patients with glioblastoma as a risk stratification biomarker in clinical management of the patients. Expand
The Potential Value of the PI3K/Akt/mTOR Signaling Pathway for Assessing Prognosis in Cervical Cancer and as a Target for Therapy
TLDR
An overview of the potential applications of the PI3K/Akt/mTOR pathway as biomarker for risk stratification, in predicting the prognosis of cervical cancer, and for developing new therapeutic approaches in patients with cervical cancer is provided. Expand
Enhanced detection sensitivity of prostate-specific antigen via PSA-conjugated gold nanoparticles based on localized surface plasmon resonance: GNP-coated anti-PSA/LSPR as a novel approach for the
TLDR
A novel approach for improving the efficacy/sensitivity of PSA in the assessment of prostate disease is established, supporting further investigation on the diagnostic value of GNP-conjugated anti-PSA/LSPR for the detection of prostate cancer. Expand
miR-211 Modulates Gemcitabine Activity Through Downregulation of Ribonucleotide Reductase and Inhibits the Invasive Behavior of Pancreatic Cancer Cells
TLDR
Functional analyses suggested the role of RRM2 as a target of miR-211 in the modulation of gemcitabine sensitivity, and inhibition of cell migration and invasion might explain the less aggressive behavior of pancreatic cancer cells with higher expression levels of mi R-211. Expand
Early detection of colorectal cancer: from conventional methods to novel biomarkers
TLDR
Increasing evidence supports the use of combined fecal and serum biomarkers with sigmoidoscopy and colonoscopy screening in order to maximize the benefits and reduce the number of false-positive tests and patients undergoing invasive methods, which in turn could overcome the limitations of the current screening methods for early detection of CRC and adenomas. Expand
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