Skip to search formSkip to main contentSkip to account menu

Tozasertib

Known as: Cyclopropanecarboxamide, n-(4-((4-(4-methyl-1-piperazinyl)-6-((5-methyl-1h-pyrazol-3-yl)amino)-2-pyrimidinyl)thio)phenyl)-, n-(4-((4-(4-methylpiperazin-1-yl)-6-((5-methyl-1h-pyrazol-3-yl)amino)pyrimidin-2-yl)sulfanyl)phenyl)cyclopropanecarboxamide 
National Institutes of Health

Related topics

Related topics

3 relations
Aurora Kinase AAurora kinase inhibitor MK-0457

Broader (1)

VX680

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
An Investigation into the Prediction of the Plasma Concentration-Time Profile and Its Interindividual Variability for a Range of Flavin-Containing Monooxygenase Substrates Using a Physiologically…
Our recent paper demonstrated the ability to predict in vivo clearance of flavin-containing monooxygenase (FMO) drug substrates… 
2017
2017
Identification of human flavin-containing monooxygenase 3 substrates by a colorimetric screening assay.
2017
2017
Apoptotic Effect of Arum dioscoridis with Tozasertib in CFPAC-1 Pancreas Carcinoma Cell Line
Silent development and progression of pancreatic cancer is also a form of cancer that is difficult to treat because of its… 
2017
2017
The Effect of Tozasertib on the Chromosomal Passanger Complex Gene Expressions in the CFPAC-1 Pancreas Carcinoma Cell Line
Aurora Kinases, a member of the serine-threonine kinase family, have crucial roles in the mechanisms of controlling the cell… 
2017
2017
Anti-Metastatic Effect of Arum dioscoridis with Tozasertib in CFPAC-1 Pancreas Carcinoma Cell Line
Metastasis, one of the most important problems encountered in the treatment of pancreatic cancer, is responsible for the death of… 
2013
2013
AEG-1 overexpression is essential for maintenance of malignant state in human AML cells via up-regulation of Akt1 mediated by AURKA activation.
2012
2012
New Kinase Inhibitors for the Treatment of Chronic Hematological Neoplasms-Editorial
Protein kinases (PKs) and lipid kinases (LKs) are good targets for signal transduction therapy, as these enzymes are involved in… 
2011
2011
Kinases A and B Vulnerability of Ewing ' s Sarcoma to Combined Inhibition of Aurora An Integrated Chemical Biology Approach Identifies Specific
Ewing’s sarcoma is a pediatric cancer of the bone that is characterized by the expression of the chimeric transcription factor… 
2010
2010
Gateways to clinical trials.
O(6)-Benzylguanine; (-)-Gossypol; Abatacept, AC-2592, Adalimumab, AIDSVAX gp120 B/E, Alemtuzumab, Aliskiren fumarate, ALVAC… 
2010
2010
Abstract 5422: Drug combination studies in a panel of 30 cell lines established from patient-derived tumor xenograft
In recent years, the focus of anticancer drug development has changed from conventional cytotoxic drugs to targeted agents… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)