VX680

Known as: VX-680, MK-0457, MK0457 
 
National Institutes of Health

Papers overview

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2011
2011
MK-0457 and MK-5108 are novel aurora kinase inhibitors (AKi) leading to G(2)-M cell-cycle arrest. Growth and survival of multiple… (More)
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2010
2010
The Aurora kinases regulate multiple aspects of mitotic progression, and their overexpression in diverse tumor types makes them… (More)
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2008
2008
Aurora A is a serine/threonine kinase that functions in various stages of mitosis. Accumulating evidence has demonstrated that… (More)
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2008
2008
What is the relationship of Aurora kinases and cancer? All three members of the Aurora kinase family are overexpressed in… (More)
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2008
2008
The demonstration that the small synthetic molecule reversine [2-(4-morpholinoanilino)-N6-cyclohexyladenine] promotes the… (More)
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Review
2008
Review
2008
Chronic myeloid leukemia (CML) is characterized by the presence of the Philadelphia (Ph) chromosome, which results from a… (More)
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Highly Cited
2007
Highly Cited
2007
MK-0457 (VX-680) is a small-molecule aurora kinase (AK) inhibitor with preclinical antileukemia activity. The T315I BCR-ABL… (More)
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Highly Cited
2007
Highly Cited
2007
Molecularly targeted kinase inhibitor cancer therapies are currently administered sequentially rather than simultaneously. We… (More)
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Highly Cited
2005
Highly Cited
2005
To realize the full potential of targeted protein kinase inhibitors for the treatment of cancer, it is important to address the… (More)
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Highly Cited
2004
Highly Cited
2004
The Aurora kinases are essential for the regulation of chromosome segregation and cytokinesis during mitosis. Aberrant expression… (More)
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