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VX680

Known as: VX-680, MK-0457, MK0457 
 
National Institutes of Health

Papers overview

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2011
2011
The inhibition of Aurora kinases in order to arrest mitosis and subsequently inhibit tumor growth via apoptosis of proliferating… Expand
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Highly Cited
2007
Highly Cited
2007
Molecularly targeted kinase inhibitor cancer therapies are currently administered sequentially rather than simultaneously. We… Expand
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Highly Cited
2007
Highly Cited
2007
MK-0457 (VX-680) is a small-molecule aurora kinase (AK) inhibitor with preclinical antileukemia activity. The T315I BCR-ABL… Expand
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Highly Cited
2007
Highly Cited
2007
The small molecule inhibitor of the Aurora-family of protein kinases VX-680 or MK-0457, demonstrates potent anti-cancer activity… Expand
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Highly Cited
2007
Highly Cited
2007
Centrosomal Aurora-A (Aur-A) kinase ensures proper spindle assembly and accurate chromosome segregation in mitosis… Expand
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Highly Cited
2007
Highly Cited
2007
VX-680, also known as MK-0457, is a member of a diverse group of small molecules that inhibit the Aurora kinases, and has shown… Expand
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Highly Cited
2006
Highly Cited
2006
We present a high-resolution (2.0 A) crystal structure of the catalytic domain of a mutant form of the Abl tyrosine kinase (H396P… Expand
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Highly Cited
2006
Highly Cited
2006
VX-680 is a potent inhibitor of Aurora kinases that induces the accumulation of cells with > or =4N DNA content, followed by cell… Expand
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Highly Cited
2005
Highly Cited
2005
To realize the full potential of targeted protein kinase inhibitors for the treatment of cancer, it is important to address the… Expand
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Highly Cited
2004
Highly Cited
2004
The Aurora kinases are essential for the regulation of chromosome segregation and cytokinesis during mitosis. Aberrant expression… Expand
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