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Toyocamycin

Known as: 7H-Pyrrolo(2,3-d)pyrimidine-5-carbonitrile, 4-amino-7-beta-D-ribofuranosyl-, Toyocamycin [Chemical/Ingredient], Deazacyanoadenosine 
4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an… 
National Institutes of Health

Related topics

Related topics

10 relations

Narrower (1)

5'-deoxytoyocamycin

Broader (2)

Antibiotics, AntineoplasticAntimetabolites, Antineoplastic
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1997
1997
Structural and functional relationships of toyocamycin on NPM-translocation.
Toyocamycin is an antitumor antibiotic which has a pyrrolo[2,3-D]pyrimidine aglycone with a -CN substituent on the 5-carbon… 
1996
1996
Synthesis of non-nucleoside analogs of toyocamycin, sangivamycin, and ++thiosangivamycin: influence of various 7-substituents on antiviral activity.
A number of 7-substituted 4-aminopyrrolo[2,3-d]pyrimidine-5-carbonitrile, -5-carboxamide, and -5-thiocarboxamide derivatives… 
1990
1990
Nucleoside inhibitors of rhodopsin kinase.
The specificity of the ATP-binding site of rhodopsin kinase was studied with adenosine analogues that are competitive inhibitors… 
1989
1989
Synthesis, cytotoxicity, and antiviral activity of certain 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine nucleosides related to toyocamycin and sangivamycin.
A number of 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine derivatives related to the nucleoside antibiotics toyocamycin and… 
1989
1989
A new biological role of sangivamycin; inhibition of protein kinases.
During the screening for the inhibitors of protein kinase C (PKC), we found that a streptomycete produced an inhibitor in our… 
1981
1981
Chromosome segregation is frequently associated with the expression of recessive mutations in mouse cells.
The genes coding for adenosine kinase (ADK; ATP:adenosine 5'-phosphotransferase, EC 2.7.1.20) and esterase-10 (ES-10… 
1981
1981
Treatment of mouse neoplasms with high doses of tubercidin.
Previous studies from this laboratory demonstrated that a potent inhibitor of nucleoside transport, nitrobenzylthioinosine (NBMPR… 
1976
1976
Synthesis and biological activity of pyrazolo[3,4,-d]pyrimidine nucleosides and nucleotides related to tubercidin, toyocamycin, and sangivamycin.
The 6-aza analogues of toyocamycin and sangivamycin were prepared as potential cytotoxic agents. The toyocamycin analogue (4… 
1973
1973
Effects of actinomycin D, toyocamycin and cycloheximide on the synthesis of low-molecular-weight nuclear RNAs in HeLa cells.
The effects of three antibiotics on the synthesis of the small-molecular-weight nuclear RNA (called small nRNA) have been… 
1969
1969
Electron microscopic studies on HeLa cells exposed to the antibiotic toyocamycin.
Summary The antibiotic toyocamycin (TCM) selectively inhibits the synthesis of ribosomal RNA in different mammalian cells by… 
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