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Toyocamycin

Known as: 7H-Pyrrolo(2,3-d)pyrimidine-5-carbonitrile, 4-amino-7-beta-D-ribofuranosyl-, Toyocamycin [Chemical/Ingredient], Deazacyanoadenosine 
4-Amino-5-cyano-7-(D-ribofuranosyl)-7H- pyrrolo(2,3-d)pyrimidine. Antibiotic antimetabolite isolated from Streptomyces toyocaensis cultures. It is an… 
National Institutes of Health

Related topics

Related topics

10 relations

Narrower (1)

5'-deoxytoyocamycin

Broader (2)

Antibiotics, AntineoplasticAntimetabolites, Antineoplastic
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1989
1989
Synthesis, cytotoxicity, and antiviral activity of certain 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine nucleosides related to toyocamycin and sangivamycin.
A number of 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine derivatives related to the nucleoside antibiotics toyocamycin and… 
1981
1981
Chromosome segregation is frequently associated with the expression of recessive mutations in mouse cells.
The genes coding for adenosine kinase (ADK; ATP:adenosine 5'-phosphotransferase, EC 2.7.1.20) and esterase-10 (ES-10… 
1981
1981
Treatment of mouse neoplasms with high doses of tubercidin.
Previous studies from this laboratory demonstrated that a potent inhibitor of nucleoside transport, nitrobenzylthioinosine (NBMPR… 
1979
1979
Protection of mice against lethal dosages of nebularine by nitrobenzylthioinosine, an inhibitor of nucleoside transport.
In the presence of nitrobenzylthioinosine (NBMPR) a potent inhibitor of nucleoside transport, Roswell Park Memorial Institute… 
1973
1973
Effects of actinomycin D, toyocamycin and cycloheximide on the synthesis of low-molecular-weight nuclear RNAs in HeLa cells.
The effects of three antibiotics on the synthesis of the small-molecular-weight nuclear RNA (called small nRNA) have been… 
1972
1972
Adenovirus messenger RNA in mammalian cells: failure of polyribosome association in the absence of nuclear cleavage.
The nuclear synthesis of adenovirus-specific RNA late in the infectious cycle in the presence of toyocamycin (an adenosine… 
1970
1970
Influence of toyocamycin on avian leukemia myeloblasts: cell growth, ultrastructure, RNA synthesis, and elaboration of BAI strain A virus.
Myeloblasts from chickens with BAI strain A virus leukemia were cultured in vitro and treated with the antibiotic toyocamycin… 
1969
1969
Electron microscopic studies on HeLa cells exposed to the antibiotic toyocamycin.
Summary The antibiotic toyocamycin (TCM) selectively inhibits the synthesis of ribosomal RNA in different mammalian cells by… 
1969
1969
Influence of toyocamycin on RNA synthesis in chick embryo cells noninfected and infected with strain MC29 avian leukosis virus.
Earlier studies showed that infection of chick embryo cells (CEC) by strain MC29 avian leukosis virus resulted in virus… 
1968
1968
Nucleoside antibiotics. I. Biochemical tools for studying the structural requirements for interaction at the catalytic and regulatory sites of ribonucleotide reductase from Lactobacillus leichmannii.
Abstract The structural requirements for reactivity at the substrate site and for interaction at the regulatory site of… 
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